gene 1,398 words KG: EIF4G1 2026-03-27
kind:genesection:genesstate:published
Contents

EIF4G1 Gene

🧬 Gene Info
Gene SymbolEIF4G1
Chromosome3p14.2
Functionis a large scaffolding protein (approximately 175 kDa) that serves as the core component of the eIF4F translation initiation complex.
Molecular Weight220 kDa
Amino Acids1598 aa
Exons33
PathwaysNF-κB, mTOR
Ensembl IDENSG00000114867
GeneCardsEIF4G1
Human Protein AtlasEIF4G1
Associated Diseasesneurodegeneration
InteractionsATG5, DISC1, IREB2, CASP1, MAPK8, ATXN2
KG Connections51 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: regulates
IREB2 — Iron Responsive Element Binding Protein 2
gene · KG edge: activates
GALNT3 — Polypeptide N-acetylgalactosaminyltransferase
gene · KG edge: regulates

Knowledge Graph (12 edges)

EIF4G1 interacts_with ATG5
EIF4G1 regulates NOX1
EIF4G1 regulates NGF
EIF4G1 activates DISC1
EIF4G1 regulates GALNT3
EIF4G1 activates IREB2
EIF4G1 expressed_in Cancer
EIF4G1 expressed_in Tumor
EIF4G1 expressed_in Autophagy
EIF4G1 expressed_in Oxidative Stress