gene 980 words KG: NOX1 2026-03-24
kind:genesection:genesstate:published
Contents

NOX1 Gene

🧬 Gene Info
Gene SymbolNOX1
Full NameNADPH Oxidase 1
ChromosomeXq22
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressioncertain neuronal populations and glial cells within the brain
Molecular Weight65 kDa
Amino Acids564 aa
PathwaysApoptosis, Complement, Exocytosis, Mitochondrial Function
UniProt ID[Q9Y5S5](https://www.uniprot.org/uniprot/Q9Y5S5)
Ensembl IDENSG00000156508
OMIM300225
GeneCardsNOX1
Human Protein AtlasNOX1
6 transmembrane domainsPosition heme groups for electron transfer
Dehydrogenase domainContains FAD and NADPH binding sites
Associated DiseasesParkinson, Parkinson's Disease, disease, ferroptosis, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsEGFR, EGF, OPTN, PPARGC1A, SIRT1, SQSTM1
KG Connections107 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Angiogenesis Pathway
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: regulates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
NBN Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

NOX1 interacts_with EGFR
NOX1 regulates NGF
NOX1 regulates DISC1
NOX1 regulates GALNT3
NOX1 regulates IREB2
NOX1 activates EGF
NOX1 associated_with ferroptosis
NOX1 interacts_with ferroptosis
NOX1 activates ferroptosis
NOX1 contributes_to Ferritin