gene 1,167 words KG: GLB1 2026-03-28
kind:genesection:genesstate:published
Contents

GLB1 Gene

🧬 Gene Info
Gene SymbolGLB1
AliasesGLB1 encodes beta-galactosidase, a lysosomal hydrolase. Deficiency causes GM1 gangliosidosis and Morquio B disease
Functionis a 677-amino acid glycoprotein that
Amino Acids677 aa
PathwaysMtor, Mitophagy, Akt
Ensembl IDENSG00000123983
GeneCardsGLB1
Human Protein AtlasGLB1
Highest activityLiver, spleen, brain, kidney
Brain regionsHigh expression in cortex, hippocampus, basal ganglia
Associated DiseasesAlzheimer, Rheumatoid Arthritis, Senescence, Tumor
Known Drugs/Compoundsrapamycin
InteractionsLC3, MKI67, MTOR, PI3K, PIK3CA, PSMA1
KG Connections126 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Oligodendrocyte White Matter Vulnerability
Score: 0.40

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Optineurin
protein · KG edge: associated_with
Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
PTEN Gene
gene · KG edge: associated_with
OPTN — Optineurin
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GLB1 associated_with PTEN
GLB1 associated_with OPTN
GLB1 activates LC3
GLB1 activates MKI67
GLB1 activates MTOR
GLB1 activates PI3K
GLB1 activates PIK3CA
GLB1 activates PSMA1
GLB1 activates PSMB5
GLB1 activates RPS6KB1