gene

AURKB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AURKB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections
0Hypotheses
0Analyses
50Outgoing
31Incoming

Summary

AURKB is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer, Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolAURKB
AliasesAURORA-B, STK12
Chromosome17p13.1
Functionis a chromosome passenger complex protein essential for mitosis and cytokinesis.
Subcellular Localization. The CPC, composed of Aurora B, survivin (BIRC5), INCENP, and Borealin, targets Aurora B to the inner centromere during
Gene TypeProtein Coding
UniProt IDQ96GD4
NCBI Gene ID921
Ensembl IDENSG00000178999
GeneCardsAURKB
Human Protein AtlasAURKB
Gene NameAurora Kinase B
Protein ProductAurora B kinase (AurB)
Expression PatternUbiquitous; highest during mitosis
Associated Diseasesneurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsMYC, CALM1, KIF5B, PVALB, SST, RANK
KG Connections88 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: AURKB — AlphaFold Q96GD4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

AURKB Gene

gene · 672 words

AURKC Protein

protein · 2291 words

Aurora Kinase C Protein

protein · 2281 words

aurkb-protein

protein · 1685 words

plk1-protein

protein · 1650 words

AURKC — Aurora Kinase C

gene · 1072 words

Pathway Diagram

graph TD
    AURKB["<b>AURKB</b>"]
    Als{"Als"}
    AURKB -->|"activates"| Als
    Senescence{"Senescence"}
    AURKB -->|"activates"| Senescence
    Ms{"Ms"}
    AURKB -->|"activates"| Ms
    Cancer{"Cancer"}
    AURKB -->|"activates"| Cancer
    Tumor{"Tumor"}
    AURKB -->|"activates"| Tumor
    AND["AND"]
    AURKB -->|"activates"| AND
    neurodegeneration["neurodegeneration"]
    AURKB -->|"implicated in"| neurodegeneration
    GENES["GENES"]
    GENES -->|"activates"| AURKB
    MYC["MYC"]
    MYC -->|"activates"| AURKB
    CANCER["CANCER"]
    CANCER -->|"activates"| AURKB
    H2AX["H2AX"]
    H2AX -->|"activates"| AURKB
    style AURKB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (57)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
Alsactivatesdisease0.65
Senescenceactivatesdisease0.65
Msactivatesdisease0.65
Canceractivatesdisease0.65

Incoming (31)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
MYCactivatesgene0.60
H2AXactivatesgene0.60
KIF15associated_withgene0.60
NEFLassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found