Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AURKB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
AURKB is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer, Ms. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | AURKB |
| Aliases | AURORA-B, STK12 |
| Chromosome | 17p13.1 |
| Function | is a chromosome passenger complex protein essential for mitosis and cytokinesis. |
| Subcellular Localization | . The CPC, composed of Aurora B, survivin (BIRC5), INCENP, and Borealin, targets Aurora B to the inner centromere during |
| Gene Type | Protein Coding |
| UniProt ID | Q96GD4 |
| NCBI Gene ID | 921 |
| Ensembl ID | ENSG00000178999 |
| GeneCards | AURKB |
| Human Protein Atlas | AURKB |
| Gene Name | Aurora Kinase B |
| Protein Product | Aurora B kinase (AurB) |
| Expression Pattern | Ubiquitous; highest during mitosis |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | MYC, CALM1, KIF5B, PVALB, SST, RANK |
| KG Connections | 88 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
AURKB["<b>AURKB</b>"]
Als{"Als"}
AURKB -->|"activates"| Als
Senescence{"Senescence"}
AURKB -->|"activates"| Senescence
Ms{"Ms"}
AURKB -->|"activates"| Ms
Cancer{"Cancer"}
AURKB -->|"activates"| Cancer
Tumor{"Tumor"}
AURKB -->|"activates"| Tumor
AND["AND"]
AURKB -->|"activates"| AND
neurodegeneration["neurodegeneration"]
AURKB -->|"implicated in"| neurodegeneration
GENES["GENES"]
GENES -->|"activates"| AURKB
MYC["MYC"]
MYC -->|"activates"| AURKB
CANCER["CANCER"]
CANCER -->|"activates"| AURKB
H2AX["H2AX"]
H2AX -->|"activates"| AURKB
style AURKB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Als | activates | disease | 0.65 |
| Senescence | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Leukemia | activates | disease | 0.65 |
| MYC | activates | gene | 0.60 |
| TPR | associated_with | gene | 0.60 |
| RANK | therapeutic_target | gene | 0.60 |
| NEFH | associated_with | gene | 0.60 |
| KIF5B | interacts_with | gene | 0.60 |
| CDC42 | associated_with | gene | 0.60 |
| PVALB | interacts_with | gene | 0.60 |
| SST | interacts_with | gene | 0.60 |
| GAP43 | associated_with | gene | 0.60 |
| RANK | interacts_with | gene | 0.60 |
| NEFL | associated_with | gene | 0.60 |
| CALM1 | associated_with | gene | 0.60 |
| KIF15 | associated_with | gene | 0.60 |
| KIF5B | associated_with | gene | 0.60 |
| PVALB | associated_with | gene | 0.60 |
| SST | associated_with | gene | 0.60 |
| CDK1 | activates | gene | 0.60 |
| DDB1 | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| GLB1 | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| STK11 | activates | gene | 0.60 |
| TSC2 | activates | gene | 0.60 |
| WIPI2 | activates | gene | 0.60 |
| MKI67 | associated_with | gene | 0.60 |
| MKI67 | interacts_with | gene | 0.60 |
| ULK1 | regulates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| ULK1 | phosphorylates | gene | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| ULK1 | inhibits | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| FBXW7 | regulates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| HUB GENES | associated_with | gene | 0.60 |
| GFP | activates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| LKB1 | activates | gene | 0.60 |
| MTORC1 | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| DNA | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| MYC | activates | gene | 0.60 |
| H2AX | activates | gene | 0.60 |
| KIF15 | associated_with | gene | 0.60 |
| NEFL | associated_with | gene | 0.60 |
| TPR | associated_with | gene | 0.60 |
| CDC42 | associated_with | gene | 0.60 |
| GAP43 | associated_with | gene | 0.60 |
| CALM1 | interacts_with | gene | 0.60 |
| KIF5B | interacts_with | gene | 0.60 |
| SST | interacts_with | gene | 0.60 |
| PVALB | interacts_with | gene | 0.60 |
| ACTB | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| AMPK | regulates | gene | 0.60 |
| AMPK | phosphorylates | gene | 0.60 |
| AMPK | inhibits | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.50 |
| NEFH | associated_with | gene | 0.50 |
| PVALB | associated_with | gene | 0.50 |
| CALM1 | associated_with | gene | 0.50 |
| KIF5B | associated_with | gene | 0.50 |
| ASPM | interacts_with | protein | 0.50 |
| ASPM | associated_with | protein | 0.50 |
| ASPM | co_expressed_with | protein | 0.50 |
| benchmark_ot_ad_answer_key:AURKB | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||