gene

ELAVL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ELAVL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

186Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ELAVL2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with ALS, Aging, Als. Connected to 101 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ELAVL2
Full Name	ELAV Like RNA Binding Protein 2
Chromosome	9p21.3
Protein Family	ELAVL (Embryonic Lethal, Abnormal Vision, Drosophila-like)
Function	ELAVL2 is a member of the ELAVL family (ELAVL1-4) that is expressed specifically in neurons and primarily localizes to the cytoplasm.
Subcellular Localization	of specific mRNAs within neurons, enabling localized protein synthesis at synapses
Molecular Weight	~36-39 kDa
Pathways	Cholesterol, Lipid Metabolism, Neurogenesis, Translation Fidelity
NCBI Gene ID	1993 (NCBI)
GeneCards	ELAVL2
Human Protein Atlas	ELAVL2
Official Symbol	ELAVL2
Protein	HuB protein
Associated Diseases	ALS, Aging, Ftd, Neurodegeneration
Interactions	IGF2BP1, FUS, BRAIN INJURY, METTL3, Proteins, RNA
KG Connections	186 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ELAVL2["ELAVL2"]
    ELAVL2 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    ELAVL2 -->|"target for"| Aging["Aging"]
    ELAVL2 -->|"target for"| Ms["Ms"]
    ELAVL2 -->|"target for"| Als["Als"]
    ELAVL2 -->|"activates"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    ELAVL2 -->|"target for"| C1Q["C1Q"]
    ELAVL2 -->|"target for"| MTOR["MTOR"]
    ELAVL2 -->|"target for"| CLPP["CLPP"]
    ELAVL2 -->|"target for"| RAB11["RAB11"]
    PI3K["PI3K"] -->|"target for"| ELAVL2
    C1Q -->|"target for"| ELAVL2
    AUTOPHAGY["AUTOPHAGY"] -->|"target for"| ELAVL2
    SNAP29["SNAP29"] -->|"target for"| ELAVL2
    MTOR -->|"target for"| ELAVL2
    IGF2BP1["IGF2BP1"] -->|"target for"| ELAVL2
    FUS["FUS"] -->|"target for"| ELAVL2
    AKT["AKT"] -->|"target for"| ELAVL2
    LONP1["LONP1"] -->|"target for"| ELAVL2
    BDNF["BDNF"] -->|"target for"| ELAVL2

Outgoing (127)

Target	Relation	Type	Str
Translation Fidelity	regulates	process	0.85
Neurodegeneration	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
ALS	associated_with	disease	0.65
Ftd	therapeutic_target	disease	0.65
Aging	encodes	disease	0.65
Neurodegeneration	encodes	disease	0.65
Als	encodes	disease	0.65
C1Q	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60
RAB11	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
RAB5	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
SNAP29	associated_with	gene	0.60
LONP1	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
FUS	regulates	entity	0.60
IGF2BP1	regulates	entity	0.60
C1Q/C3	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
TDP-43	therapeutic_target	gene	0.60
SNAP29	encodes	gene	0.60
FUS	encodes	gene	0.60
TDP-43	encodes	gene	0.60
STX17	encodes	gene	0.60
RAB5	encodes	gene	0.60
CLPP	encodes	gene	0.60
BDNF	encodes	gene	0.60
IGF2BP1	encodes	gene	0.60
RAB11	encodes	gene	0.60
Sumo	therapeutic_target	protein	0.60
Rb	therapeutic_target	protein	0.60

Incoming (59)

Source	Relation	Type	Str
AKT	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
C1Q	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
CD44	associated_with	gene	0.60
GFAP	activates	gene	0.60
LGALS3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
FUS	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
C1Q/C3	associated_with	gene	0.60
RAB11	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
STX17	associated_with	gene	0.60
IGF2BP1	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
LONP1	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
CLPP	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
RAB5	therapeutic_target	gene	0.60
TDP-43	associated_with	gene	0.60
TDP-43	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
FN1	activates	gene	0.60
LYSOSOME	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
AGING	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
METTL3	associated_with	gene	0.60
METTL3	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
LYSOSOME	therapeutic_target	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
WNT	associated_with	gene	0.60
MAPK	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ELAVL2

Understanding Entity Pages

Summary

Wiki Pages (8)

ELAVL2 Gene

IGF2BP1

ELAVL1 Gene

ELAVL4 Protein

ELAVL3 Gene

ELAVL4 Gene