gene 1,564 words KG: KDR 2026-03-28
kind:genesection:genestopic:alzheimerstopic:parkinsons
Contents

KDR Gene

🧬 Gene Info
Gene SymbolKDR
AliasesVEGFR2
Chromosome4q12
Protein TypeReceptor
Functionis a receptor tyrosine kinase that serves as the primary signaling receptor for VEGF-mediated angiogenesis and vascular development.
Molecular Weight230 kDa
Amino Acids356 aa
Exons30
PathwaysFunction
GeneCardsKDR
Human Protein AtlasKDR
PathwayFunction
PI3K/AKTSurvival, NO production
MAPK/ERKProliferation
PLCγ-PKCCalcium signaling
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsMMP9, ICAM1, SPP1, MMP2, NOS2, POU5F1
KG Connections55 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Retinal Vascular Microcirculation Rescue
Score: 0.54
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.50
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: associated_with
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: therapeutic_target
Angiogenesis Pathway
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: biomarker_for
MMP9 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

KDR inhibits MMP9
KDR inhibits ICAM1
KDR inhibits SPP1
KDR inhibits MMP2
KDR inhibits NOS2
KDR biomarker_for FGF9
KDR biomarker_for HSPG2
KDR associated_with HRAS
KDR associated_with STAT1
KDR therapeutic_target RAGE