| Gene Symbol | LAMP1 |
| Full Name | Lysosomal Associated Membrane Protein 1 |
| Chromosome | 13q34 |
| Protein Family | LAMP family |
| Protein Type | Structural Protein |
| Target Class | Structural Protein |
| Function | Protects lysosomal membrane proteins from proteolytic degradation |
| Mechanism of Action | Direct LAMP1 modulators enhance lysosomal membrane trafficking and autophagy flux, while indirect pathway drugs alter lysosomal pH and autophagosome-lysosome fusion dynamics to modulate LAMP1-mediated cellular clearance mechanisms. |
| Primary Expression | Ubiquitous, highest in brain |
| Druggability | Low (0.43) |
| Clinical Stage | Phase I |
| Molecular Weight | 120 kDa |
| Amino Acids | 417 aa |
| Pathways | mTOR |
| UniProt ID | P11279 |
| GeneCards | LAMP1 |
| Human Protein Atlas | LAMP1 |
| Associated Diseases | AD, ADH, Als, Alzheimer, Alzheimer disease severity |
| Known Drugs/Compounds | COENZYME Q10, rapamycin, RAPAMYCIN |
| Interactions | ABCA1, ACHE, ACLY, ACTB, Actin, AD |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Lysosomal Positioning Dynamics Modulation Lysosomal Membrane Stabilization to Prevent Tau Se |
| KG Connections | 1588 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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