gene 783 words KG: NUCKS1 2026-03-24
kind:genesection:genesstate:published
Contents

NUCKS1 Gene

🧬 Gene Info
Gene SymbolNUCKS1
Full NameNUCKS1, Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1
Chromosome1q32.1
Protein TypeKinase
FunctionNUCKS1 encodes a nuclear protein that serves as a substrate for several kinases, including casein kinases and cyclin-dependent kinases.
Primary Expressionneurons and glial cells, where it may play roles in neuronal survival and response to cellular stress
Molecular Weight66 kDa
PathwaysEpigenetic
UniProt IDQ9H0U4
NCBI Gene ID64766
Ensembl IDENSG00000138231
GeneCardsNUCKS1
Human Protein AtlasNUCKS1
StrategyApproach
Gene expression modulationTarget NUCKS1 transcriptional regulators
Associated DiseasesALS, Ms, Parkinson
InteractionsJUN, DNA, PARKINSON'S DISEASE, PARKINSON, Actin
KG Connections89 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Packard Center for ALS Research
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
GPNMB Gene
gene · KG edge: associated_with
GCH1 Gene
gene · KG edge: associated_with
DRD2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NUCKS1 associated_with SLC6A2
NUCKS1 associated_with SLC6A3
NUCKS1 associated_with SNCA
NUCKS1 associated_with ABCB1
NUCKS1 associated_with APOE
NUCKS1 associated_with CYP2D6
NUCKS1 associated_with SLC6A4
NUCKS1 transports CYP2D6
NUCKS1 transports SLC6A2
NUCKS1 activates JUN