| Gene Symbol | OGG1 |
| Chromosome | 3p26.2<br> |
| Function | OGG1 is a bifunctional DNA glycosylase that both excises 8-oxoG from damaged DNA and cleaves the abasic site that remains. |
| Primary Expression | all brain regions with highest levels in:
- Hippocampus (dentate gyrus, CA3)
- Cerebral cortex (layer V pyramidal neuron |
| Molecular Weight | 39 kDa |
| Pathways | Autophagy, Dna Repair, Mitophagy, Mtor, Oxidative Stress |
| UniProt ID | O15527 |
| NCBI Gene ID | 4967 |
| Ensembl ID | ENSG00000114026 |
| GeneCards | OGG1 |
| Human Protein Atlas | OGG1 |
| 8-oxoG Removal | Primary enzyme for excising 8-oxoguanine lesions |
| AP Site Processing | Creates substrate for APE1 and DNA polymerase β |
| Mutagenesis Prevention | Prevents G:C to T:A transversions caused by 8-oxoG |
| Transcriptional Regulation | 8-oxoG in promoters can affect gene expression |
| Associated Diseases | neurodegeneration, neuroinflammation |
| Interactions | BLM, PARKIN, SIRT3, MFN1, TFAM, LONP1 |
| KG Connections | 66 knowledge graph edges |
| Databases | GeneCardsHPASTRING |