gene 630 words KG: PDGFRA 2026-03-21
kind:genesection:genesstate:published
Contents

PDGFRA - Platelet Derived Growth Factor Receptor Alpha

🧬 Gene Info
Gene SymbolPDGFRA
Full NamePDGFRA - Platelet Derived Growth Factor Receptor Alpha
AliasesPage for PDGFRA
Chromosome4q12
Protein TypeGene
FunctionPDGFRA signaling regulates cell proliferation, migration, and survival during development and tissue repair [@uniprot]:
Primary Expressionmesenchymal cells including fibroblasts, smooth muscle cells, and glial progenitors [@references]
Molecular Weight180 kDa
Amino Acids1086 aa
Exons23
PathwaysAkt, Differentiation, MAPK signaling, ubiquitin-proteasome
NCBI Gene IDSearch NCBI
GeneCardsPDGFRA
Human Protein AtlasPDGFRA
Associated DiseasesALS, Cancer, Carcinoma, Glioma, Tumor
InteractionsPDGFRB, IL6R, AKT, EPHA2, GBM, PDGFA
SciDEX HypothesesOPC differentiation blockade contributes to white
KG Connections105 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (8)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
OPC differentiation blockade contributes to white matter deg
Score: 0.50
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47

Related Analyses (7)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

PDGFRA and C-MYC protein validation in ovarian cancer tissue
exploratory · proposed · Score: 0.85
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: inhibits
erk-mapk-signaling-neurodegeneration
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: expressed_in
NF1 — Neurofibromin 1
gene · KG edge: associated_with
MYC Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PDGFRA interacts_with PDGFRB
PDGFRA associated_with PI3K
PDGFRA associated_with AKT
PDGFRA activates IL6R
PDGFRA activates AKT
PDGFRA inhibits EPHA2
PDGFRA inhibits GBM
PDGFRA inhibits PDGFA
PDGFRA regulates GLI1
PDGFRA contributes_to PDGFRB