gene 1,700 words KG: TNFR2 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:alstopic:neuroinflammation
Contents

TNFRSF1B Gene

🧬 Gene Info
Gene SymbolTNFRSF1B
AliasesTNFR2, p75, TNF-R2, TNF-R75
Chromosome1p36.22
Protein TypeReceptor
Functionencodes a type I membrane receptor for tumor necrosis factor (TNF).
Primary ExpressionUbiquitous
Molecular Weight75 kDa
Amino Acids461 aa
Exons10
PathwaysNF-κB, NF-κB pathway, PI3K, MAPK pathway, MAPK Pathway
UniProt IDP20333
NCBI Gene ID7133
Ensembl IDENSG00000028137
GeneCardsTNFRSF1B
Human Protein AtlasTNFRSF1B
Associated DiseasesCancer, Chronic Pain, Leukemia, Lung Cancer, Pain
InteractionsTNFRSF13C, HCRTR1, GRIN3B, CRH, WNT11, MYO7A
KG Connections59 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Multi-Modal Stress Response Harmonization
Score: 0.60
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48
Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.46

Related Analyses (4)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
CAT — Catalase
gene · KG edge: associated_with
casp3
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TNFR2 regulates SYNAPTIC_FUNCTION
TNFR2 regulates SYNAPTIC_PLASTICITY
TNFR2 expressed_in TNFR1
TNFR2 associated_with BCL2
TNFR2 associated_with SLC16A1
TNFR2 regulates TNF
TNFR2 regulates GFAP
TNFR2 interacts_with TNFR1
TNFR2 interacts_with TNF
TNFR2 inhibits TNF