gene 2,789 words KG: PLCG2
Contents

PLCG2 Gene

🧬 Gene Info
Gene SymbolPLCG2
Full NamePhospholipase C Gamma 2
Chromosome16q23.3
Protein TypeEnzyme
Primary Expressionhematopoietic cells and microglia
Molecular Weight150 kDa
Amino Acids265 aa
PathwaysMAPK
UniProt IDP16885
NCBI Gene ID5336
Ensembl IDENSG00000197943
OMIM600220
GeneCardsPLCG2
Human Protein AtlasPLCG2
Associated DiseasesAD, AD risk, Aging, Als, Alzheimer, Alzheimer's disease
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta
SciDEX HypothesesCalibrated PLCG2 activation can reproduce the prot
PLCG2 Allosteric Modulation as a Precision Therape
Rare TREM2-TYROBP pathway variants complement stan
KG Connections361 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
← Prevpg 2/2

Related Analyses (11)

Which cell types show the most significant expression change
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (10)

Packard Center for ALS Research
institution · KG edge: associated_with
ABCA7 (Redirect)
redirect · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PLCG2 implicated_in cancer
PLCG2 implicated_in carcinoma
PLCG2 implicated_in ovarian cancer
TREM2 associated_with PLCG2
PLCG2 associated_with ABCA7
PLCG2 associated_with APOE
ABI3 regulates PLCG2
TREM2 regulates PLCG2
NDUFAF7 associated_with PLCG2
SHARPIN associated_with PLCG2

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