gene 2,789 words KG: PLCG2 2026-03-25
kind:genesection:genesstate:published
Contents

PLCG2 Gene

🧬 Gene Info
Gene SymbolPLCG2
Full NamePhospholipase C Gamma 2
Chromosome16q23.3
Protein TypeEnzyme
Primary Expressionhematopoietic cells and microglia
Molecular Weight150 kDa
Amino Acids265 aa
PathwaysMAPK
UniProt IDP16885
NCBI Gene ID5336
Ensembl IDENSG00000197943
OMIM600220
GeneCardsPLCG2
Human Protein AtlasPLCG2
Associated DiseasesAD, Aging, Als, Alzheimer, Alzheimer'S Disease
InteractionsAPOE ε4, APOE, TAU, TREM2, LRP1, PIK3R1
KG Connections379 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (26)

Microglial TREM2-Independent Pathway Activation
Score: 0.46
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
TREM2-Dependent Microglial Senescence Transition
Score: 0.69

Related Analyses (10)

Which cell types show the most significant expression change
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (10)

Packard Center for ALS Research
institution · KG edge: associated_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates
adam17
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PLCG2 contributes_to ABCB1
PLCG2 contributes_to PARP1
PLCG2 contributes_to DOT1L
PLCG2 implicated_in cancer
PLCG2 implicated_in carcinoma
PLCG2 implicated_in ovarian cancer
PLCG2 associated_with ABCA7
PLCG2 associated_with SORL1
PLCG2 associated_with APOE
PLCG2 associated_with CHRNE