gene 2,789 words KG: PLCG2
Contents

PLCG2 Gene

🧬 Gene Info
Gene SymbolPLCG2
Full NamePhospholipase C Gamma 2
Chromosome16q23.3
Protein TypeEnzyme
Primary Expressionhematopoietic cells and microglia
Molecular Weight150 kDa
Amino Acids265 aa
PathwaysMAPK
UniProt IDP16885
NCBI Gene ID5336
Ensembl IDENSG00000197943
OMIM600220
GeneCardsPLCG2
Human Protein AtlasPLCG2
Associated DiseasesAD, AD risk, Aging, Als, Alzheimer, Alzheimer's disease
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta
SciDEX HypothesesCalibrated PLCG2 activation can reproduce the prot
PLCG2 Allosteric Modulation as a Precision Therape
Rare TREM2-TYROBP pathway variants complement stan
KG Connections361 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
APOE-Dependent Autophagy Restoration
Score: 0.89
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
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Related Analyses (11)

Which cell types show the most significant expression change
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (10)

Packard Center for ALS Research
institution · KG edge: associated_with
ABCA7 (Redirect)
redirect · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PLCG2 implicated_in cancer
PLCG2 implicated_in carcinoma
PLCG2 implicated_in ovarian cancer
TREM2 associated_with PLCG2
PLCG2 associated_with ABCA7
PLCG2 associated_with APOE
ABI3 regulates PLCG2
TREM2 regulates PLCG2
NDUFAF7 associated_with PLCG2
SHARPIN associated_with PLCG2

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