gene 2,940 words KG: PLIN1 2026-03-25
kind:genesection:genesstate:published
Contents

PLIN1 — Perilipin 1

🧬 Gene Info
Gene SymbolPLIN1
Full NamePerilipin 1
Chromosome15q26.1
Protein FamilyPerilipin family (PLIN1, PLIN2, PLIN3, PLIN4, PLIN5)
Functionis a peripheral membrane protein that associates with the phospholipid monolayer that surrounds neutral lipid droplets.
Primary Expressionadipocytes, where it plays an essential role in regulating lipid storage and mobilization by protecting stored triglycerides from lipolytic enzymes an
Molecular Weight56 kDa
Amino Acids522 aa
PathwaysApoptosis, Autophagy, Pi3K/Akt
UniProt IDQ13441 (PLIN1_HUMAN)
NCBI Gene ID5346
Ensembl IDENSG00000141579
OMIM170650
GeneCardsPLIN1
Human Protein AtlasPLIN1
Associated DiseasesAging, Ms
InteractionsMFN1, MFN2, PPARG, ABCG1, GLUT4, PARP1
KG Connections40 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Microbial Inflammasome Priming Prevention
Score: 0.58
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.48
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Extracellular Matrix Stiffness Modulation
Score: 0.43

Related Analyses (3)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
MMP9 Gene
gene · KG edge: expressed_in
mfn2
gene · KG edge: activates

Knowledge Graph (12 edges)

PLIN1 associated_with HSP90AB1
PLIN1 associated_with MAP1LC3B
PLIN1 expressed_in IGF1
PLIN1 expressed_in P2RY14
PLIN1 expressed_in MMP9
PLIN1 expressed_in FOS
PLIN1 expressed_in TAC1
PLIN1 expressed_in SPP1
PLIN1 activates MFN1
PLIN1 activates MFN2