protein

SIRPA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIRPA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

SIRPA is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, associated with, implicated in. Associated with Als, Alzheimer, Cancer. Connected to 37 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	SIRPA
Chromosome	20p13
Function	SIRPA (Signal Regulatory Protein Alpha) is a transmembrane protein that primarily expressed on macrophages, dendritic cells, and neurons.
Primary Expression	neurons, may regulate synaptic function
Amino Acids	504 aa
Pathways	Complement
Ensembl ID	ENSG00000198053
GeneCards	SIRPA
Human Protein Atlas	SIRPA
CD47	Primary ligand of SIRPA; expressed on neuronal surfaces
SHP-1/SHP-2	Protein tyrosine phosphatases recruited by SIRPA
Microglia	Primary CNS cells expressing SIRPA
Neuroinflammation	Broader
Associated Diseases	Aging, Alzheimer, Senescence
Interactions	TPP1, VEGFB, TMEM106B, CD47, C1R, C1S
KG Connections	107 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SIRPA["<b>SIRPA</b>"]
    Alzheimer{"Alzheimer"}
    SIRPA -->|"therapeutic target"| Alzheimer
    Ms{"Ms"}
    SIRPA -->|"therapeutic target"| Ms
    Dementia{"Dementia"}
    SIRPA -->|"therapeutic target"| Dementia
    Als{"Als"}
    SIRPA -->|"therapeutic target"| Als
    GRN["GRN"]
    SIRPA -->|"associated with"| GRN
    neurodegeneration["neurodegeneration"]
    SIRPA -->|"implicated in"| neurodegeneration
    TREM2["TREM2"]
    TREM2 -->|"associated with"| SIRPA
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| SIRPA
    CTSH["CTSH"]
    CTSH -->|"associated with"| SIRPA
    TMEM106B["TMEM106B"]
    TMEM106B -->|"associated with"| SIRPA
    SIGLEC9["SIGLEC9"]
    SIGLEC9 -->|"associated with"| SIRPA
    style SIRPA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (52)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.75
Alzheimer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Medulloblastoma	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	regulates	disease	0.65
Aging	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
ALS	regulates	disease	0.65
GRN	associated_with	gene	0.60
C1QC	regulates	gene	0.60
C1S	regulates	gene	0.60
MERTK	regulates	gene	0.60
ITGAM	regulates	gene	0.60
C1QA	regulates	gene	0.60
CD47	regulates	gene	0.60
C1QB	regulates	gene	0.60
C1R	regulates	gene	0.60
complement cascade	participates_in	pathway	0.60
TPP1	interacts_with	gene	0.60
VEGFB	interacts_with	gene	0.60
TMEM106B	associated_with	gene	0.60
TMEM106B	interacts_with	gene	0.60
Immunotherapy	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Dna Methylation	therapeutic_target	pathway	0.60
Phagocytosis	therapeutic_target	pathway	0.60
Histone Modification	therapeutic_target	pathway	0.60
Nf-Kb	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
AGING	associated_with	gene	0.60
Microglia	regulates	cell_type	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
Complement	regulates	pathway	0.60
Complement System	regulates	pathway	0.60
microglia	expressed_in	cell_type	0.60
Alzheimer's disease	interacts_with	disease	0.60
Parkinson's disease	interacts_with	disease	0.60
ALS	interacts_with	disease	0.60
multiple sclerosis	interacts_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
blood-brain barrier	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
oligodendrocytes	expressed_in	cell_type	0.60

Incoming (55)

Source	Relation	Type	Str
CLN5	interacts_with	gene	0.70
TREM2	associated_with	gene	0.60
CTSH	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
SIGLEC9	associated_with	gene	0.60
TGM2	therapeutic_target	gene	0.60
CD47	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
C1QB	regulates	gene	0.60
C1R	regulates	gene	0.60
C1QC	regulates	gene	0.60
C1S	regulates	gene	0.60
MERTK	regulates	gene	0.60
C3	regulates	gene	0.60
C1R	interacts_with	gene	0.60
C1S	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
SIGLEC9	interacts_with	gene	0.60
CLN5	associated_with	gene	0.60
CTSH	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
NF-KB	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
PHAGOCYTOSIS	therapeutic_target	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AGING	associated_with	gene	0.60
GENES	regulates	gene	0.60
SYNAPTIC PRUNING	associated_with	gene	0.60
AND	regulates	gene	0.60
COMPLEMENT GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
C1QA	activates	gene	0.50
C1QB	activates	gene	0.50
C1QC	activates	protein	0.50
C1R	activates	gene	0.50
C1S	activates	gene	0.50
ITGAM	activates	protein	0.50
MERTK	activates	gene	0.50
late	regulates	disease	0.50
C1QA	regulates	gene	0.50
ITGAM	regulates	protein	0.50
late	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SIRPA

Understanding Entity Pages

Summary

Wiki Pages (9)

SIRPA Gene

SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

Epigenetic Biomarkers in Neurodegenerative Diseases

CD47-SIRPα Immune Checkpoint Therapy

CLN5 Gene - Ceroid Lipofuscinosis, Neuronal 5

CD47 Gene

SIRPA Protein

Proteins