gene 2,721 words KG: SLC16A2
Contents

SLC16A2 Gene (MCT8)

🧬 Gene Info
Gene SymbolSLC16A2
Full NameMonocarboxylate transporter 8
Protein Familytransporter
Target ClassTransporter
Mechanism of ActionSubstrate supplementation or transporter modulation
DruggabilityLow (0.39)
Clinical StagePhase I
PathwaysX chromosome, SLC16 family, thyroid function, Blood-Brain Barrier, Lactate/monocarboxylate transport
GeneCardsSLC16A2
Human Protein AtlasSLC16A2
Associated DiseasesAging, ALI, Allan-Herndon-Dudley syndrome, Als, AMI
Known Drugs/CompoundsTriiodothyroacetic acid
InteractionsC1Q, CANCER, CYP2E1, GSS, JUN, MCT8
SciDEX TargetView Target Profile (1 clinical trials)
SciDEX HypothesesAstrocytic Lactate Shuttle Enhancement for Grid Ce
KG Connections154 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57
← Prevpg 2/2

Related Analyses (5)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40
s:** - Test MCU overexpression specifically in layer II neur
falsification · proposed · Score: 0.40

See Also (8)

Gerstmann-Straussler-Scheinker Syndrome (GSS)
disease · KG edge: activates
Genes
index · KG edge: associated_with
ATL1
gene · KG edge: associated_with
C1QA Gene — Complement Component 1q A Chain
gene · KG edge: activates
COL4A1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PPARGC1A co_discussed SLC16A2
SLC16A2 co_discussed RELN
SLC16A2 co_discussed MAP6
SLC16A2 co_discussed HCN1
SLC16A2 co_discussed MCU
SLC16A2 co_discussed IDH2
JUN therapeutic_target SLC16A2
SLC16A2 regulates Astrocytic Lactate Shuttle Enhancement for Grid Ce
SLC16A2 associated_with SLC16A1
SLC16A2 therapeutic_target GSS

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