gene

GSS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

83Connections

0Hypotheses

0Analyses

50Outgoing

18Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	GSS
Full Name	Glutathione Synthetase
Aliases	GSH-S
Chromosome	20q11.22
Function	Catalyzes second step of glutathione biosynthesis
Molecular Weight	52.4 kDa
Amino Acids	474
Pathways	Glutathione biosynthesis, Oxidative stress defense
UniProt ID	P48637
Ensembl ID	ENSG00000100983
GeneCards	GSS
Human Protein Atlas	GSS
Associated Diseases	AD, AMI, ARM, Ms, RA, SS
Interactions	JUN, SLC16A2, PTBP1, P38, SLC7A11, GPX4
KG Connections	83 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GSS — AlphaFold P48637 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GSS["GSS"] -->|"therapeutic target"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    GSS["GSS"] -.->|"inhibits"| Ischemia["Ischemia"]
    style Ischemia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    GSS["GSS"] -->|"activates"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    GSS["GSS"] -.->|"inhibits"| Stroke["Stroke"]
    style Stroke fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    GSS["GSS"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    GSS["GSS"] -->|"activates"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    GSS["GSS"] -->|"expressed in"| Diabetes["Diabetes"]
    style Diabetes fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    JUN["JUN"] -->|"therapeutic target"| GSS["GSS"]
    style JUN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    SLC16A2["SLC16A2"] -->|"therapeutic target"| GSS["GSS"]
    style SLC16A2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ACSL5["ACSL5"] -->|"therapeutic target"| GSS["GSS"]
    style ACSL5 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    SPHK1["SPHK1"] -->|"expressed in"| GSS["GSS"]
    style SPHK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CYP2E1["CYP2E1"] -->|"activates"| GSS["GSS"]
    style CYP2E1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style GSS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (65)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	activates	disease	0.65
Stroke	inhibits	disease	0.65
Ischemia	protects_against	disease	0.65
Stroke	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Diabetes	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
JUN	activates	gene	0.60
SLC16A2	activates	gene	0.60
PTBP1	activates	gene	0.60
P38	activates	gene	0.60
SLC7A11	activates	gene	0.60
GPX4	activates	gene	0.60
TLR4	activates	gene	0.60
GFAP	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
TFAM	associated_with	gene	0.60
SPHK1	expressed_in	gene	0.60
JUN	therapeutic_target	gene	0.60
SLC16A2	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
MICRORNAS	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
Ferroptosis	activates	pathway	0.60
Oxidative Stress	inhibits	pathway	0.60
Mapk	inhibits	pathway	0.60
ASTROCYTES	activates	gene	0.60
NF-ΚB	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
MITOCHONDRIAL DNA	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
MTDNA	expressed_in	gene	0.60
Histone Modification	expressed_in	pathway	0.60
Dna Methylation	expressed_in	pathway	0.60
Epigenetic	expressed_in	pathway	0.60
CYP2E1	activates	gene	0.60
ACSL5	activates	gene	0.60
CANCER	activates	gene	0.60
MIR-375	activates	gene	0.60
ASTROCYTE	activates	gene	0.60

Incoming (18)

Source	Relation	Type	Str
JUN	therapeutic_target	gene	0.60
SLC16A2	therapeutic_target	gene	0.60
SPHK1	expressed_in	gene	0.60
TLR4	activates	gene	0.60
NRF2	expressed_in	gene	0.60
JUN	activates	gene	0.60
ACSL5	therapeutic_target	gene	0.60
ACSL5	activates	gene	0.60
CYP2E1	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
STROKE	activates	gene	0.60
AND	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
MIR-375	activates	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
CANCER	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GSS

Understanding Entity Pages

Wiki Pages (21)

Gerstmann-Straussler-Scheinker Syndrome (GSS)

calcium-dysregulation-comparison

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

prion-disease

Fatal Familial Insomnia

Variably Protease-Sensitive Prionopathy (VPSPr)

Prion Protein (PRNP)

Prion Strain Diversity and Selective Vulnerability

Prion Protein

Diseases

Glutathione Metabolism Pathway

huntingtons-disease-like-1

section-197-advanced-clinical-trial-design-cbs-psp

creutzfeldt-jakob

GSS Gene (Glutathione Synthetase)

Prion-Infected Neurons

Prion Protein Metabolism in Neurodegeneration

Disease Classification & Relationships

kuru