gene 953 words KG: TIA1
Contents

TIA1 - TIA1 Cytotoxic Granule Associated RNA Binding Protein

🧬 Gene Info
Gene SymbolTIA1
Full NameTIA1 Cytotoxic Granule Associated RNA Binding Protein
AliasesPage for TIA1
Chromosome2p16.3
Protein FamilyTIA1/TIAR family
FunctionTIA1 functions as a multifunctional RNA-binding protein with critical roles in several cellular processes.
Molecular Weight43 kDa
Amino Acids386 aa
PathwaysEr Stress
UniProt IDP52912
NCBI Gene ID4678
Ensembl IDENSG00000173166
OMIM603518
GeneCardsTIA1
Human Protein AtlasTIA1
Associated DiseasesAls, amyotrophic lateral sclerosis, dementia
Known Drugs/Compoundsrapamycin
InteractionsALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, APOPTOSIS, App
KG Connections258 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Axonal RNA Transport Reconstitution
Score: 0.70
Cross-Seeding Prevention Strategy
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
RNA Granule Nucleation Site Modulation
Score: 0.66
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (11)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (11)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: activates
ATF4 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GABARAP associated_with TIA1
ATF4 associated_with TIA1
FMR1 associated_with TIA1
MTOR associated_with TIA1
RRAGA interacts_with TIA1
G3BP1 associated_with TIA1
JUN interacts_with TIA1
RRAGB interacts_with TIA1
TIA1 associated_with EIF2A
JUN activates TIA1

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