disease

Cystic Fibrosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Cystic Fibrosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

0Analyses

11Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	PAH, ATG, ROS, AUTOPHAGY, TNF, CFTR, TGFB1, MAP1LC3B
KG Connections	70 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (16)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Cystic_Fibrosis["Cystic Fibrosis"] -->|"associated"| Mtor["Mtor"]
    style Mtor fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Cystic_Fibrosis["Cystic Fibrosis"] -->|"associated"| Autophagy["Autophagy"]
    style Autophagy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Cystic_Fibrosis["Cystic Fibrosis"] -->|"activates"| Lipid_Metabolism["Lipid Metabolism"]
    style Lipid_Metabolism fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Cystic_Fibrosis["Cystic Fibrosis"] -->|"associated"| Pulmonary_Fibrosis["Pulmonary Fibrosis"]
    style Pulmonary_Fibrosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Cystic_Fibrosis["Cystic Fibrosis"] -->|"regulates"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Cystic_Fibrosis["Cystic Fibrosis"] -->|"activates"| Bacterial_Infection["Bacterial Infection"]
    style Bacterial_Infection fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Cystic_Fibrosis["Cystic Fibrosis"] -->|"activates"| Insulin_Resistance["Insulin Resistance"]
    style Insulin_Resistance fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Fibrosis["Fibrosis"] -->|"associated"| Cystic_Fibrosis["Cystic Fibrosis"]
    style Fibrosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PAH["PAH"] -->|"associated"| Cystic_Fibrosis["Cystic Fibrosis"]
    style PAH fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ATG["ATG"] -->|"associated"| Cystic_Fibrosis["Cystic Fibrosis"]
    style ATG fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ROS["ROS"] -->|"associated"| Cystic_Fibrosis["Cystic Fibrosis"]
    style ROS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    AUTOPHAGY["AUTOPHAGY"] -->|"associated"| Cystic_Fibrosis["Cystic Fibrosis"]
    style AUTOPHAGY fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Cystic_Fibrosis fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (11)

Target	Relation	Type	Str
Mtor	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Lipid Metabolism	activates	pathway	0.60
Pulmonary Fibrosis	associated_with	disease	0.55
Inflammation	regulates	disease	0.55
Inflammation	associated_with	disease	0.55
Bacterial Infection	activates	disease	0.55
Inflammation	activates	disease	0.55
Insulin Resistance	activates	disease	0.55
Inflammation	causes	disease	0.55
Diabetes	associated_with	disease	0.55

Incoming (60)

Source	Relation	Type	Str
Fibrosis	associated_with	disease	0.75
PAH	associated_with	gene	0.65
ATG	associated_with	gene	0.65
ROS	associated_with	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
TNF	associated_with	gene	0.65
INFLAMMATION	regulates	gene	0.65
CFTR	associated_with	gene	0.65
TGFB1	associated_with	gene	0.65
MAP1LC3B	associated_with	gene	0.65
MTOR	associated_with	gene	0.65
STAT3	associated_with	gene	0.65
IL1B	associated_with	gene	0.65
INFLAMMATION	associated_with	gene	0.65
GENES	causes	gene	0.65
CFTR	causes	gene	0.65
TLR9	associated_with	gene	0.65
Fibrosis	causes	disease	0.65
INSULIN RESISTANCE	activates	gene	0.65
SQSTM1	activates	gene	0.65
INFLAMMATION	activates	gene	0.65
P62	activates	gene	0.65
ATM	activates	gene	0.65
INFLAMMATION	causes	gene	0.65
CYTOKINES	treats	gene	0.65
GENES	treats	gene	0.65
DIABETES MELLITUS	associated_with	gene	0.65
CANCER	associated_with	gene	0.65
GENES	therapeutic_target	gene	0.65
GENE MUTATIONS	therapeutic_target	gene	0.65
BPI-ANCA	associated_with	entity	0.60
Tumor	associated_with	disease	0.55
Infection	regulates	disease	0.55
Hypertension	associated_with	disease	0.55
Copd	associated_with	disease	0.55
Asthma	regulates	disease	0.55
Infection	activates	disease	0.55
Fibrosis	activates	disease	0.55
Metabolic Syndrome	activates	disease	0.55
Infection	causes	disease	0.55
Als	treats	disease	0.55
Cancer	associated_with	disease	0.55
AMBRA1	activates	protein	0.50
AKT1	activates	gene	0.50
ATF6	activates	gene	0.50
ATG16L1	activates	gene	0.50
Autophagy	activates	process	0.50
CGAS	activates	protein	0.50
BECN1	activates	gene	0.50
CFTR	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Cystic Fibrosis

Understanding Entity Pages

Wiki Pages (16)

RNF5 — RING Finger Protein 5

ANO9 — Anoctamin 9

Gilead Sciences

ANO8 (Anoctamin 8)

Spinal Muscular Atrophy (SMA)

CFTR Gene

Abetalipoproteinemia

4D Molecular Therapeutics

ALS10 - Amyotrophic Lateral Sclerosis 10 (TARDBP)

CDK5 Inhibitors for Neurodegeneration

SCNN1A Gene

Vertex Pharmaceuticals

TLR9 — Toll-Like Receptor 9

Moderna Therapeutics