gene 1,820 words KG: UCP2 2026-03-26
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:als
Contents

UCP2 — Uncoupling Protein 2

🧬 Gene Info
Gene SymbolUCP2
Full NameUCP2 — Uncoupling Protein 2
Chromosome11q13.4
Protein TypeProtein
FunctionUCP2 is a mitochondrial anion carrier protein that uncouples oxidative phosphorylation:
Amino Acids309 aa
PathwaysAMPK
UniProt IDSearch UniProt
NCBI Gene IDSearch NCBI
GeneCardsUCP2
Human Protein AtlasUCP2
Associated DiseasesAlzheimer's disease, Parkinson's disease, ALS
InteractionsASC, AIM2, INFLAMMATION, MICROGLIA ACTIVATION, NEUROINFLAMMATION, MICROGLIA
KG Connections105 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
PARP1 Inhibition Therapy
Score: 0.58
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: inhibits
EGR1 Gene
gene · KG edge: therapeutic_target
DRP1 Gene - Dynamin 1-Like Protein
gene · KG edge: regulates

Knowledge Graph (12 edges)

UCP2 associated_with PINK1
UCP2 regulates PARKIN
UCP2 inhibits ASC
UCP2 inhibits AIM2
UCP2 associated_with VDAC1
UCP2 inhibits Als
UCP2 regulates Cardiac
UCP2 regulates Ms
UCP2 regulates Ischemia
UCP2 associated_with Mitophagy