gene 684 words KG: UFM1
Contents

UFM1 — Ubiquitin-like Modifier 1

🧬 Gene Info
Gene SymbolUFM1
Full NameUbiquitin-like Modifier 1
Functionencodes a ubiquitin-like protein that undergoes unique post-translational modification through ufmylation.
Subcellular Localization- Cytoplasm, particularly near the ER
Amino Acids83 aa
PathwaysAutophagy
GeneCardsUFM1
Human Protein AtlasUFM1
UFM1The ubiquitin-like modifier itself, encoded by the UFM1 gene
UFC1 (UFM1-conjugating enzyme 1)An E1-like enzyme that activates UFM1 in an ATP-dependent manner
UFL1 (UFM1 ligase 1)An E3-like enzyme that facilitates transfer of UFM1 to target proteins
Associated DiseasesAls, Alzheimer, Cancer, dementia, frontotemporal
InteractionsAMPK, ASC1, ATG14, AUTOPHAGY, BECN1, FERROPTOSIS
KG Connections91 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

VCP-Mediated Autophagy Enhancement
Score: 0.59
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (3)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (12)

Ubiquitin-Proteasome System Therapeutic Companies for P
company · KG edge: associated_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

MAP1LC3B regulates UFM1
VCP activates UFM1
UFM1 regulates ATXN3
UFM1 activates BECN1
UFM1 interacts_with NLRP3
UFM1 associated_with MAVS
UFM1 activates VCP
UFM1 regulates UBIQUITIN
UFM1 regulates MAP1LC3B
UFM1 expressed_in SLC7A11

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