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mechanism 2,303 words KG: GSK3
Contents

gsk3-parkinsons

⚙ Mechanism Info
NameGSK3
Key Genes/ProteinsABL1, ACAT1, ACETYL-COA, Actin, AGING, AIF
Related DiseasesAging, Als, ALS, Alzheimer, Alzheimer's disease
Related PathwaysAkt
Linked Hypotheses2 hypotheses

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Related Hypotheses (11)

RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA P
Score: 0.86hnRNP A2/B1 Staufen2-Mediated Axonal RNA Granule Transport F
Score: 0.83MAP6-CRMPS cooperative phosphorylation by GSK3β
Score: 0.70A post-trigger CDK5-dominant kinase feedback loop maintains
Score: 0.59H3: Reelin Signaling Deficiency Uncouples Layer II Neurons f
Score: 0.56Synergistic reduction of amyloid-tau interaction through sec
Score: 0.50P2RY12/P2RY13 Purinergic Receptor Metabolic Rewiring
Score: 0.49Amyloid Plaque Clearance Triggers Downstream Reduction in Ta
Score: 0.48Mitochondrial Dysfunction Increasing Neuronal Vulnerability
Score: 0.47Reactive astrocytes and cholinesterase-rich low-acetylcholin
Score: 0.44GSK3β Inhibition to Prevent α-Synuclein Phosphorylation and
Score: 0.43

Knowledge Graph (12 edges)

GSK3 interacts_with MTOR
CDK5 associated_with GSK3
GSK3 associated_with MARK4
GSK3 associated_with Alzheimer's disease
AKT activates GSK3
MTOR activates GSK3
PI3K activates GSK3
AMPK activates GSK3
BECN1 activates GSK3
LC3 activates GSK3

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