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mechanism 1,055 words KG: GABA
Contents

GABA Signaling Pathway

⚙ Mechanism Info
NameGABA
Key Genes/ProteinsABCA7, ACTB, Actin, ADRA2B, Akt, AKT
Related Diseasesacetylcholine, Aging, AGING, Als, ALS
Linked Hypotheses16 hypotheses

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🌐 Cross-references

Wikipedia

Related Hypotheses (84)

Multi-Modal Stress Response Harmonization
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75Circadian-Synchronized Proteostasis Enhancement
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74Phase-Separated Organelle Targeting
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71HDAC3-Selective Inhibition for Clock Reset
Score: 0.71Mitochondrial Transfer Pathway Enhancement
Score: 0.70...
Score: 0.68Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67Mitochondrial RNA Granule Rescue Pathway
Score: 0.66Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
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Related Analyses (30)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (3)

Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40Non-Dopaminergic Neurotransmitter Degeneration in PD - Exper
clinical · proposed · Score: 0.40

See Also (7)

acetylcholine
general · KG edge: co_discussedACTB Gene
gene · KG edge: activatesadra2b Gene
gene · KG edge: expressed_inAKT1 Gene
gene · KG edge: interacts_withGene Page: ALS4 (SENATAXIN)
gene · KG edge: activates

Knowledge Graph (12 edges)

GABA associated_with MTOR
GABA associated_with TFEB
AKT associated_with GABA
BACE1 associated_with GABA
TAU associated_with GABA
GABA associated_with neuroinflammation
GABA associated_with serotonin
GABA associated_with GABAergic neurons
GABA interacts_with GABARAP
FLCN interacts_with GABA

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