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mechanism 1,055 words KG: GABA
Contents

GABA Signaling Pathway

⚙ Mechanism Info
NameGABA
Key Genes/ProteinsABCA7, ACTB, Actin, ADRA2B, Akt, AKT
Related Diseasesacetylcholine, Aging, AGING, Als, ALS
Linked Hypotheses16 hypotheses

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Wikipedia

Related Hypotheses (84)

Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64TREM2-mediated microglial tau clearance enhancement
Score: 0.62Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61Netrin-1 Gradient Restoration
Score: 0.59VCP-Mediated Autophagy Enhancement
Score: 0.59TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58Synaptic Vesicle Tau Capture Inhibition
Score: 0.58HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76Circadian Clock-Autophagy Synchronization
Score: 0.76
← Prevpg 3/5Next →

Related Analyses (30)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (3)

Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40Non-Dopaminergic Neurotransmitter Degeneration in PD - Exper
clinical · proposed · Score: 0.40

See Also (7)

acetylcholine
general · KG edge: co_discussedACTB Gene
gene · KG edge: activatesadra2b Gene
gene · KG edge: expressed_inAKT1 Gene
gene · KG edge: interacts_withGene Page: ALS4 (SENATAXIN)
gene · KG edge: activates

Knowledge Graph (12 edges)

GABA associated_with MTOR
GABA associated_with TFEB
AKT associated_with GABA
BACE1 associated_with GABA
TAU associated_with GABA
GABA associated_with neuroinflammation
GABA associated_with serotonin
GABA associated_with GABAergic neurons
GABA interacts_with GABARAP
FLCN interacts_with GABA

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