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mechanism 2,025 words KG: GSK3
Contents

GSK3-beta Signaling Pathway

⚙ Mechanism Info
NameGSK3
Key Genes/ProteinsABL1, ACAT1, ACETYL-COA, Actin, AGING, AIF
Related DiseasesAging, Als, ALS, Alzheimer, Alzheimer's disease
Related PathwaysAkt
Linked Hypotheses3 hypotheses

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🌐 Cross-references

Wikipedia

Related Hypotheses (70)

Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Mitochondrial Transfer Pathway Enhancement
Score: 0.70Mitochondrial RNA Granule Rescue Pathway
Score: 0.66FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Sphingolipid Metabolism Reprogramming
Score: 0.62SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61LRP1-Dependent Tau Uptake Disruption
Score: 0.60Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57
← Prevpg 4/4

Related Analyses (30)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (8)

iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90AMPK knockdown validation experiment
exploratory · proposed · Score: 0.88iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85Mouse Cdk5, p35, and p39 mutations in neuronal migration
validation · proposed · Score: 0.80Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40

See Also (3)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activatesAlzheimer Indonesia
institution · KG edge: activatesAging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates

Knowledge Graph (12 edges)

GSK3 interacts_with MTOR
CDK5 associated_with GSK3
GSK3 associated_with MARK4
GSK3 associated_with Alzheimer's disease
AKT activates GSK3
MTOR activates GSK3
PI3K activates GSK3
AMPK activates GSK3
BECN1 activates GSK3
LC3 activates GSK3

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