| Gene Symbol | PIK3C3 |
| Aliases | VPS34 |
| Chromosome | 18q12.3 |
| Protein Family | Class III Phosphoinositide 3-kinase (PI3K3C) |
| Function | PIK3C3 contributes to lysosomal biogenesis and function through its role in autophagosome-lysosome fusion. The protein interacts with the HOPS complex via VPS34-generated PI3P |
| Subcellular Localization | Cytosol, endosomal membrane, phagophore |
| Molecular Weight | 100 kDa |
| Amino Acids | 887 aa |
| Exons | 32 |
| Pathways | PI3K |
| UniProt ID | Q8N3F7 |
| Ensembl ID | ENSG00000055070 |
| GeneCards | PIK3C3 |
| Human Protein Atlas | PIK3C3 |
| Associated Diseases | AD, ADH, Als, Alzheimer, AMI |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACAT1, ACETYL-COA, AKT, AKT1, AKT1S1, ALZHEIMER |
| KG Connections | 1124 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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