protein 842 words KG: FTL 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Ferritin Light Chain (FTL)

🔬 Protein Info
Gene SymbolFTL
Chromosome19q13.33
FunctionFe²⁺ entry: Iron enters through 3-fold hydrophilic channels
Primary Expressionhippocampus, Hippocampus
Molecular Weight20 kDa
Exons4
PathwaysLipid Metabolism, Mitophagy, Autophagy, Oxidative Stress, Ferroptosis
UniProt ID[P02792](https://www.uniprot.org/uniprot/P02792)
GeneCardsFTL
Human Protein AtlasFTL
Associated DiseasesALS, Dystonia, Leukemia, Ms, Neurodegeneration
InteractionsAPP, Rb, GPX4, SLC7A11, TFR1, PANK2
KG Connections120 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (3)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson'
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (8)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
FTH1 Gene — Ferritin Heavy Chain 1
gene · KG edge: expressed_in
FGF19 — Fibroblast Growth Factor 19
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FTL associated_with WDR45
FTL associated_with COASY
FTL associated_with DCAF17
FTL associated_with FA2H
FTL associated_with C19ORF12
FTL associated_with PANK2
FTL associated_with PLA2G6
FTL component_of FERRITINLIGHTPROTEIN
FTL expressed_in TFR1
FTL expressed_in FTH1