protein 876 words KG: GSDMD 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Gasdermin D Protein

🔬 Protein Info
Gene SymbolGSDMD
Functionis a gene encoding a key executor of pyroptotic cell death
Primary Expressionhippocampus, temporal lobe, cortex, Substantia Nigra, Ca1
Molecular Weight56 kDa
Amino Acids484 aa
PathwaysApoptosis, Ferroptosis, Inflammasome, Necroptosis, Oxidative Stress
GeneCardsGSDMD
Human Protein AtlasGSDMD
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Cancer, Cardiovascular
Known Drugs/Compoundscurcumin, natural products, Qingqi Liangying Formula, XHP, Pterostilbene
InteractionsSCD1, HMGCR, TNF, MLKL, ACSL4, MYD88
KG Connections880 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (18)

Microbial Inflammasome Priming Prevention
Score: 0.58
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42
Multi-Modal Stress Response Harmonization
Score: 0.60

Related Analyses (14)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (6)

Alzheimer Indonesia
institution · KG edge: activates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: activates
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: inhibits
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibits
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activates

Knowledge Graph (12 edges)

GSDMD inhibits SCD1
GSDMD inhibits HMGCR
GSDMD inhibits TNF
GSDMD inhibits MLKL
GSDMD inhibits ACSL4
GSDMD activates MYD88
GSDMD inhibits FASN
GSDMD inhibits ALOX15
GSDMD activates TLR4
GSDMD activates NLRP3