protein 1,547 words KG: HDAC4 2026-03-28
kind:proteinsection:proteinsstate:published
Contents

HDAC4 Protein

🔬 Protein Info
Gene SymbolHDAC4
Full NameHistone Deacetylase 4
Chromosome2q37.3
Protein FamilyHistone deacetylase, Class IIa
FunctionHistone Modification: Removes acetyl groups from lysine tails of histones H3 and H4
Subcellular Localization</strong></td><td>Nucleus/Cytoplasm (signal-dependent shuttling)</td></tr>
Molecular Weight119 kDa
Amino Acids1088 aa
PathwaysNF-κB, AMPK
UniProt ID[P56524](https://www.uniprot.org/uniprot/P56524)
Ensembl IDENSG00000113048
OMIM605314
GeneCardsHDAC4
Human Protein AtlasHDAC4
Associated DiseasesALS, Aging, Alzheimer, Soft Tissue Sarcoma, Tumor, dementia
InteractionsMEF2A, AQP1, TNF, CDK2, HUNTINGTIN, DNAJB6
KG Connections182 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.56

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (6)

SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice
validation · proposed · Score: 0.90
HDAC4 inhibition and NHE6 expression mechanism study
exploratory · proposed · Score: 0.85
Neuroimmune modulation and Aβ clearance mechanisms
exploratory · proposed · Score: 0.82
Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Dementia Australia
institution · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: regulates
CDK4 Gene
gene · KG edge: inhibits
CDK2 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

HDAC4 inhibits MEF2A
HDAC4 inhibits AQP1
HDAC4 therapeutic_target AKT
HDAC4 associated_with HDAC7
HDAC4 therapeutic_target PI3K
HDAC4 associated_with PTEN
HDAC4 associated_with AKT
HDAC4 associated_with PI3K
HDAC4 interacts_with MEF2
HDAC4 causes Transformation