protein 1,365 words KG: HSP60 2026-03-24
kind:proteinsection:proteinsstate:published
Contents

HSP60 (Heat Shock Protein 60)

🔬 Protein Info
Gene SymbolHSP60
Full NameHSP60 (Heat Shock 60)
AliasesHsp60 protein, Heat Shock Protein 60
Protein TypeProtein
Functionis a mitochondrial chaperonin protein essential for proper protein folding within the mitochondrion.
Primary Expressiontestis and some peripheral tissues
Molecular Weight60.3 kDa
PathwaysApoptosis, Autophagy, Mapk, Mitophagy, Nf-Κb
UniProt IDSearch UniProt
GeneCardsHSP60
Human Protein AtlasHSP60
Associated Diseasesneurodegeneration
Known Drugs/Compoundsmemantine
InteractionsPARKIN, OPTINEURIN, GRIA2, PTEN, COX4I1, PINK1
KG Connections208 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.39

Related Analyses (9)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: causes
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: contributes_to
Alzheimer Indonesia
institution · KG edge: activates
DnaJ Heat Shock Protein Family (Hsp40) Member C7
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

HSP60 activates PARKIN
HSP60 activates OPTINEURIN
HSP60 activates GRIA2
HSP60 activates PTEN
HSP60 activates COX4I1
HSP60 activates PINK1
HSP60 activates MAP1LC3B
HSP60 activates USP30
HSP60 expressed_in Brainstem
HSP60 activates OPTN