protein 1,612 words KG: MAP2 2026-03-24
kind:proteinsection:proteinsstate:published
Contents

MAP2 Protein — Microtubule-Associated Protein 2

🔬 Protein Info
Gene SymbolMAP2
Full NameMAP2 — Microtubule-Associated 2
AliasesMicrotubule-Associated Protein 2
Protein TypeProtein
Functionis a neuronal cytoskeletal protein that plays essential roles in dendritic arborization, synaptic stability, and microtubule stabilization in neurons[@dehmelt2003].
Primary Expressionneuronal cell bodies and dendrites, where it serves as a critical organizer of the dendritic cytoskeleton[@binder1985]
Molecular Weight280 kDa
PathwaysApoptosis, Autophagy, Dna Methylation, Epigenetic, Glycolysis
UniProt IDSearch UniProt
GeneCardsMAP2
Human Protein AtlasMAP2
Associated DiseasesAD, ALI, ALS, AMI, Aging
Known Drugs/Compoundsrapamycin
InteractionsMAP1B, MAP6, ACTB, ATG7, ESR1, ESR2
KG Connections392 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (15)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.48

Related Analyses (15)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (8)

s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (6)

Alzheimer Indonesia
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: regulates
ATG7 Gene
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates

Knowledge Graph (12 edges)

MAP2 interacts_with MAP1B
MAP2 interacts_with MAP6
MAP2 associated_with SYN1
MAP2 associated_with CTSD
MAP2 associated_with MAP1LC3B
MAP2 associated_with SNAP25
MAP2 associated_with CTSB
MAP2 associated_with SYT1
MAP2 associated_with TFEB
MAP2 associated_with MTOR