protein 535 words KG: NOS1 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Neuronal Nitric Oxide Synthase

🔬 Protein Info
Gene SymbolNOS1
AliasesNitric Oxide Synthase 1
Chromosome12q24.2
Protein TypeEnzyme
FunctionNOS1 produces nitric oxide, which serves multiple functions in the nervous system.
Subcellular LocalizationCytoplasm, Membrane
Molecular Weight160 kDa
PathwaysMAPK signaling, lipid metabolism, oxidative stress response
UniProt IDP70689 (mouse), Q9WU75 (rat)
Ensembl IDENSG00000089250
GeneCardsNOS1
Human Protein AtlasNOS1
Associated DiseasesAls, neuroinflammation, oxidative stress
InteractionsIL6, APOE, SERPINA3, CD44, MAPK1, CLU
KG Connections73 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.42
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Context-Dependent CRISPR Activation in Specific Neuronal Sub
Score: 0.51
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.47
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.40

Related Analyses (6)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (15)

Alzheimer Indonesia
institution · KG edge: interacts_with
LRP1-Enhanced Perivascular Drainage Therapy
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2
gene · KG edge: associated_with
MT1A (Metallothionein-1A)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NOS1 regulates CFTR
NOS1 associated_with EPHB4
NOS1 associated_with MMP2
NOS1 regulates HIP1R
NOS1 interacts_with IL6
NOS1 interacts_with APOE
NOS1 interacts_with SERPINA3
NOS1 associated_with PRDX6
NOS1 associated_with MT1A
NOS1 interacts_with CD44