protein 646 words KG: PANX1
Contents

PANX1 Protein

🔬 Protein Info
Gene SymbolPANX1
Full NamePannexin 1
Chromosome11q14.2
Protein FamilyPannexin family
Protein TypeChannel
Functionis a channel-forming protein that releases ATP and other signaling molecules from cells.
Subcellular LocalizationPlasma membrane, endoplasmic reticulum
Molecular Weight1 kDa
Amino Acids426 aa
PathwaysLIPID METABOLISM, Lipid Metabolism, apoptosis pathway, lipid metabolism, mitochondrial function
UniProt IDQ96HY7
NCBI Gene ID9399
Ensembl IDENSG00000110234
OMIM608421
GeneCardsPANX1
Human Protein AtlasPANX1
Associated DiseasesAls, Alzheimer, Inflammation, neurodegeneration, neuroinflammation
InteractionsActin, adora2b, ADORA2B, F3, GENES, NLRP1
SciDEX HypothesesGap Junction Hemichannel Modulation for Controlled
KG Connections143 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (16)

Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36
Purinergic Signaling Polarization Control
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.68
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Score: 0.55
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
Synthetic Biology Approach: Designer Mitochondrial Export Sy
Score: 0.51
Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48
Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48

Related Analyses (9)

Mitochondrial transfer between neurons and glia
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90
Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (10)

ATP P2X3 Receptor Neurons
cell · KG edge: associated_with
nad-augmentation-therapy-early-ad
general · KG edge: associated_with
Genes
index · KG edge: activates
ADORA2B Gene
gene · KG edge: activates
BNIP3L — BCL2 Interacting Protein 3 Like (NIX)
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

ADORA2B activates PANX1
P2RY12 activates PANX1
P2RX1 activates PANX1
P2RX4 activates PANX1
P2RX7 activates PANX1
CD38 associated_with PANX1
P2RY1 activates PANX1
P2RX5 activates PANX1
PANX1 activates P2X7
PANX1 activates SRC

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