protein 646 words KG: PANX1 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

PANX1 Protein

🔬 Protein Info
Gene SymbolPANX1
Full NamePannexin 1
Chromosome11q14.2
Protein FamilyPannexin family
Protein TypeChannel
Functionis a channel-forming protein that releases ATP and other signaling molecules from cells.
Subcellular LocalizationPlasma membrane, endoplasmic reticulum
Molecular Weight1 kDa
Amino Acids426 aa
PathwaysLIPID METABOLISM, Lipid Metabolism, apoptosis pathway, lipid metabolism, mitochondrial function
UniProt IDQ96HY7
NCBI Gene ID9399
Ensembl IDENSG00000110234
OMIM608421
GeneCardsPANX1
Human Protein AtlasPANX1
Associated DiseasesALS, Alzheimer, Inflammation, Parkinson, neurodegeneration
InteractionsP2X7, SRC, P2RX1, P2RX5, P2RY12, P2RX7
SciDEX HypothesesGap Junction Hemichannel Modulation for Controlled
KG Connections144 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.39
Purinergic Signaling Polarization Control
Score: 0.55
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Microglial Purinergic Reprogramming
Score: 0.48

Related Analyses (9)

Mitochondrial transfer between neurons and glia
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90
Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (10)

P2RX7 Gene
gene · KG edge: activates
P2RX5 Gene
gene · KG edge: activates
P2RX4 Gene
gene · KG edge: activates
P2RX1 Gene
gene · KG edge: activates
CD38 Molecule (CD38)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PANX1 activates P2X7
PANX1 activates SRC
PANX1 activates P2RX1
PANX1 associated_with CD38
PANX1 activates P2RX5
PANX1 activates P2RY12
PANX1 regulates S100B
PANX1 regulates RELB
PANX1 regulates P2RY1
PANX1 regulates CASP3