protein 1,373 words KG: SNAP25 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

SNAP-25

🔬 Protein Info
Gene SymbolSNAP
AliasesSNAP25
Target ClassStructural Protein
FunctionSnap 25 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Mechanism of ActionProtein cleavage by botulinum toxin or small molecule modulators of SNARE complex formation
DruggabilityLow (0.33)
Clinical StageApproved
GeneCardsSNAP
Human Protein AtlasSNAP
Human Brain ExpressionSearchable expression data across brain regions
Cell Type SpecificityExpression patterns in different neuronal populations
Associated DiseasesALS, ALZHEIMER'S DISEASE, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, rapamycin
InteractionsACTB, STX11, ACTG1, SNCA, GAPDH, MAPK1
SciDEX TargetView Target Profile (2 clinical trials)
SciDEX HypothesesSynaptic Vesicle Tau Capture Inhibition
Synaptic Vesicle Tau Capture Inhibition
KG Connections629 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Synaptic Vesicle Tau Capture Inhibition
Score: 0.34
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Optogenetic restoration of hippocampal gamma oscillations vi
Score: 0.57
TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S
Score: 0.55

Related Analyses (12)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (6)

Prion Strain Diversity and Selective Vulnerability
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecu
clinical · proposed · Score: 0.40

See Also (5)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
ACTB Gene
gene · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates

Knowledge Graph (12 edges)

SNAP25 activates SQSTM1
SNAP25 activates SYN1
SNAP25 activates SYT1
SNAP25 activates TFEB
SNAP25 activates TUBB3
SNAP25 activates TUBULIN
SNAP25 regulates Synaptic Vesicle Tau Capture Inhibition
SNAP25 regulates Tau Propagation
SNAP25 associated_with CTSB
SNAP25 associated_with SYT1