protein 2,914 words KG: SORL1 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

SORL1 Protein

🔬 Protein Info
Gene SymbolSORL1
Full NameSortilin-Related Receptor 1 (Sorterin)
AliasesSortilin-Related Receptor 1
Chromosome11q23.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain, particularly in neurons of the hippocampus, cortex, and cerebel
Molecular Weight250 kDa
Amino Acids214 aa
Exons48
PathwaysAmyloid, Blood-Brain Barrier, Dysbiosis, Endocytosis, Epigenetic
UniProt IDQ92606
NCBI Gene ID6653
Ensembl IDENSG00000137642
OMIM602215
GeneCardsSORL1
Human Protein AtlasSORL1
Associated DiseasesALS, Aging, Alzheimer, Alzheimer'S Disease
InteractionsBACE1, APP, APOE, TAU, SNCA, SNCAIP
KG Connections802 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
adam17
gene · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SORL1 associated_with LRP12
SORL1 interacts_with BACE1
SORL1 interacts_with APP
SORL1 interacts_with APOE
SORL1 interacts_with TAU
SORL1 interacts_with SNCA
SORL1 interacts_with SNCAIP
SORL1 interacts_with GSK3B
SORL1 interacts_with CDK5
SORL1 interacts_with MAPT