gene 1,842 words KG: SNCAIP 2026-03-27
kind:genesection:genesstate:publishedtopic:parkinsonspathway:alpha-synuclein-aggregation
Contents

SNCAIP Gene

🧬 Gene Info
Gene SymbolSNCAIP
Full NameSynphilin-1 (Alpha-Synuclein Interacting Protein)
AliasesSynphilin-1
Chromosome5q23.1
Functionis a 777-amino acid protein that plays critical roles in protein aggregation, degradation pathways, and neuronal survival.
Molecular Weight91 kDa
Amino Acids777 aa
PathwaysMAPK signaling, Reactive Oxygen Species, Wnt signaling, apoptosis, apoptosis pathway
UniProt ID[O60341](https://www.uniprot.org/uniprot/O60341)
Ensembl IDENSG00000145341
GeneCardsSNCAIP
Human Protein AtlasSNCAIP
Associated DiseasesAD, ALI, ALS, Alzheimer, Parkinson
InteractionsRB1CC1, MFN1, ERN1, PARKIN, FMR1, SNCA
KG Connections469 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (18)

Smartphone-Detected Motor Variability Correction
Score: 0.56
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (15)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: implicated_in
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with

Knowledge Graph (12 edges)

SNCAIP interacts_with RB1CC1
SNCAIP interacts_with MFN1
SNCAIP interacts_with ERN1
SNCAIP interacts_with PARKIN
SNCAIP interacts_with FMR1
SNCAIP interacts_with SNCA
SNCAIP interacts_with FAM134B
SNCAIP interacts_with LC3
SNCAIP interacts_with EPAS1
SNCAIP interacts_with MIRO1