protein 764 words KG: TRPM2 2026-03-19
kind:proteinsection:proteinsstate:published
Contents

TRPM2 (Transient Receptor Potential Melastatin 2)

🔬 Protein Info
Gene SymbolTRPM2
Full NameTransient Receptor Potential Cation Channel Subfamily M Member 2
AliasesPage for TRPM2, Page for TRPM2 Protein, Transient Receptor Potential Melastatin 2
Chromosome21q22.12
Protein TypeChannel
Functionis a calcium-permeable cation channel activated by oxidative stress and ADP-ribose.
Molecular Weight203 kDa
Amino Acids1705 aa
PathwaysOxidative Stress
UniProt IDTRPM2
Ensembl IDENSG00000086848
GeneCardsTRPM2
Human Protein AtlasTRPM2
Associated DiseasesALS, BIPOLAR_DISORDER, Bipolar, Bipolar Disorder, Depression
InteractionsTLR4, ULK1, OXIDATIVE STRESS, AMPK, VPS34, IGF2BP2
KG Connections137 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
PARP1 Inhibition Therapy
Score: 0.58
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47

Related Analyses (8)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

HTR2A Gene
gene · KG edge: associated_with
GRM4 Gene
gene · KG edge: associated_with
GRM3 — Glutamate Metabotropic Receptor 3
gene · KG edge: associated_with
GRIN2B — NMDA Receptor Subunit 2B
gene · KG edge: associated_with
GABRA5 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TRPM2 associated_with BIPOLAR_DISORDER
TRPM2 associated_with GRM3
TRPM2 associated_with DRD1
TRPM2 associated_with BMAL1
TRPM2 associated_with GABRA5
TRPM2 associated_with DAO
TRPM2 associated_with NRG1
TRPM2 associated_with GRIN2B
TRPM2 associated_with RGS4
TRPM2 associated_with NCAM1