protein 683 words KG: VIMENTIN 2026-03-29
kind:proteinsection:proteinstopic:alzheimerstopic:parkinsons
Contents

Vimentin Protein

🔬 Protein Info
Gene SymbolVIMENTIN
Protein FamilyType III intermediate filament protein
Functionis a type III intermediate filament protein encoded by the VIM gene.
Primary Expressionmesenchymal cells, fibroblasts, and astrocytes in the central nervous system
Subcellular LocalizationCytoplasm, intermediate filaments
Molecular Weight57 kDa
Amino Acids466 aa
PathwaysAutophagy, NOTCH_SIGNALING, Notch Signal Sending, Notch Signaling, Proteasome
UniProt IDP08670
GeneCardsVIMENTIN
Human Protein AtlasVIMENTIN
Associated DiseasesGlioblastoma, Ms, Tumor
Known Drugs/Compoundscolumbianadin
InteractionsFNDC5, FGF21, SOX2, GFAP, NOTCH1, DLK2
KG Connections325 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Complement C1q Subtype Switching
Score: 0.44
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51

Related Analyses (11)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

See Also (10)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: biomarker_for
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: biomarker_for
ATG14 Gene
gene · KG edge: activates
ALDH1L1
gene · KG edge: expressed_in
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

VIMENTIN regulates NOTCH_SIGNALING
VIMENTIN regulates ATG14
VIMENTIN biomarker_for C1Q
VIMENTIN activates FNDC5
VIMENTIN activates FGF21
VIMENTIN expressed_in NESTIN
VIMENTIN inhibits SOX2
VIMENTIN inhibits GFAP
VIMENTIN inhibits NOTCH1
VIMENTIN expressed_in ALDH1L1