🧫
s:** - Compare tau strain spreading in EXT1/EXT2 conditional knockout mice - Test whether HSPG-deficient astrocytes still form tufts vs plaques when e
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-debate-ca942ead922d
🧫 Experiment Protocol
Falsification
Metadata
| experiment_type | falsification |
| source | {'type': 'manual', 'source_name': 'debate_extraction', 'extraction_date': '2026-04-16T01:00:16.909390Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['EXT1'], 'diseases': ['Neurodegeneration']} |
| model_system | mouse |
| summary | # s:** - Compare tau strain spreading in EXT1/EXT2 conditional knockout mice - Test whether HSPG-deficient astrocytes still form tufts vs plaques when e ## Background and Rationale This experiment inv |
| replication_status | single_study |
| methodology_notes | **Phase 1: Animal Preparation and Genotyping (Weeks 1-2)** • Generate EXT1/EXT2 floxed mice crossed with GFAP-Cre or Aldh1l1-Cre lines for astrocyte-specific conditional knockout (n=60 total) • Genoty |
| primary_outcome | Comparative analysis of tau pathology spreading patterns and morphological characteristics (tufts vs plaques) in EXT1/EXT2 conditional knockout versus control mice at 3 and 6 months post-injection. |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from debate_extraction source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.909395'} |
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