Brain Insulin Resistance with Glucose Transporter Dysfunction

Brain Insulin Resistance with Glucose Transporter Dysfunction proposes that neuronal insulin signaling failure — a central metabolic feature of Alzheimer's disease often called "type 3 diabetes" — drives neurodegeneration through impaired glucose transporter (GLUT3/GLUT4) trafficking, energy crisis, and compensatory metabolic shifts that exacerbate tau phosphorylation and amyloid pathology. **Background and Rationale** The brain consumes approximately 20% of the body's total glucose despite co...