MET - MET Proto-Oncogene, Receptor Tyrosine Kinase

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MET - MET Proto-Oncogene, Receptor Tyrosine Kinase

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wiki page Created: 2026-04-02T07:19:19 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-met

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MET Gene — MET Proto-Oncogene, Receptor Tyrosine Kinase

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">MET - MET Proto-Oncogene, Receptor Tyrosine Kinase</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td>MET</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>MET Proto-Oncogene, Receptor Tyrosine Kinase</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>7q31.2</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>4233</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>164860</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000105976</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>P08581</td>
</tr>
<tr>
<td class="label">Protein Size</td>
<td>1390 amino acids</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~140 kDa (precursor), ~170 kDa (mature)</td>
</tr>
<tr>
<td class="label">Pathway</td>
<td>Function</td>
</tr>
<tr>
<td class="label">PI3K/AKT</td>
<td>Cell survival, growth</td>
</tr>
<tr>
<td class="label">MAPK/ERK</td>
<td>Proliferation, differentiation</td>
</tr>
<tr>
<td class="label">STAT</td>
<td>Transcription regulation</td>
</tr>
<tr>
<td class="label">PLCγ</td>
<td>Calcium signaling</td>
</tr>
<tr>
<td class="label">Drug</td>
<td>Mechanism</td>
</tr>
<tr>
<td class="label">Crizotinib</td>
<td>MET inhibitor</td>
</tr>
<tr>
<td

...

MET Gene — MET Proto-Oncogene, Receptor Tyrosine Kinase

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">MET - MET Proto-Oncogene, Receptor Tyrosine Kinase</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td>MET</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>MET Proto-Oncogene, Receptor Tyrosine Kinase</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>7q31.2</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>4233</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>164860</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000105976</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>P08581</td>
</tr>
<tr>
<td class="label">Protein Size</td>
<td>1390 amino acids</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~140 kDa (precursor), ~170 kDa (mature)</td>
</tr>
<tr>
<td class="label">Pathway</td>
<td>Function</td>
</tr>
<tr>
<td class="label">PI3K/AKT</td>
<td>Cell survival, growth</td>
</tr>
<tr>
<td class="label">MAPK/ERK</td>
<td>Proliferation, differentiation</td>
</tr>
<tr>
<td class="label">STAT</td>
<td>Transcription regulation</td>
</tr>
<tr>
<td class="label">PLCγ</td>
<td>Calcium signaling</td>
</tr>
<tr>
<td class="label">Drug</td>
<td>Mechanism</td>
</tr>
<tr>
<td class="label">Crizotinib</td>
<td>MET inhibitor</td>
</tr>
<tr>
<td class="label">Cabozantinib</td>
<td>Multi-kinase inhibitor</td>
</tr>
<tr>
<td class="label">Tepotinib</td>
<td>Selective MET inhibitor</td>
</tr>
<tr>
<td class="label">AMG 208</td>
<td>MET inhibitor</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/ad" style="color:#ef9a9a">AD</a>, <a href="/wiki/ali" style="color:#ef9a9a">ALI</a>, <a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/ami" style="color:#ef9a9a">AMI</a>, <a href="/wiki/aging" style="color:#ef9a9a">Aging</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">479 edges</a></td>
</tr>
</table>

Pathway Diagram

Mermaid diagram (expand to render)

Introduction

The MET gene (MET Proto-Oncogene, Receptor Tyrosine Kinase) encodes the hepatocyte growth factor receptor (HGFR), a receptor tyrosine kinase that plays crucial roles in cell growth, survival, migration, and tissue morphogenesis. In the nervous system, MET signaling is important for neuronal development, migration, and synaptic plasticity, and is implicated in neurodegenerative diseases and brain cancers[@maina2001].

Gene Information

Protein Structure

MET is a heterodimeric receptor:

α-subunit ( extracellular): Ligand binding
β-subunit (transmembrane): Contains tyrosine kinase domain
Semaphorin (Sema) domain: HGF binding
Tyrosine Kinase Domain: Catalytic activity (Y1234, Y1235)
C-terminal Docking Sites: Multiple tyrosine residues for signaling

Normal Neuronal Function

Brain Development

Neuronal Migration: Critical for cortical neuron migration
Axon Guidance: Directs axon growth cones
Dendritic Arborization: Promotes dendrite outgrowth
Synapse Formation: Regulates synaptic development

Plasticity and Repair

Synaptic Plasticity: Involved in learning and memory
Neurogenesis: Regulates neural stem cell function
Axon Regeneration: Promotes regeneration after injury

Astrocyte Function

Astrocyte Development: Important for astrocyte maturation
Glial Support: Supports neuronal survival

Expression Pattern

MET is expressed in various tissues:

Brain: Neurons, astrocytes, neural progenitor cells
Liver, kidney, muscle
Endothelial cells
Epithelial cells

In the brain, MET expression is highest during development and decreases in adulthood.

Disease Associations

Alzheimer's Disease

Synaptic Dysfunction: Altered MET signaling in AD brain
Aβ Interaction: Amyloid-beta affects MET signaling
Cognitive Decline: Linked to memory deficits

Parkinson's Disease

Dopaminergic Neurons: MET in substantia nigra
Neuroprotection: HGF/MET signaling is neuroprotective
Therapeutic Potential: MET agonists being explored

Brain Cancer

Oncogenic Role: MET amplification in glioblastoma
Invasion: Promotes tumor cell invasion
Therapeutic Target: MET inhibitors in clinical trials

Autism Spectrum Disorders

Genetic Associations: MET variants linked to ASD risk
Synaptic Function: Altered cortical connectivity

Signaling Pathways

MET activates multiple downstream pathways:

Therapeutic Targeting

External Links

[NCBI Gene: MET](https://www.ncbi.nlm.nih.gov/gene/4233)
[UniProt: P08581](https://www.uniprot.org/uniprot/P08581)
[OMIM: 164860](https://www.omim.org/entry/164860)
[GeneCards: MET](https://www.genecards.org/cgi-bin/carddisp.pl?gene=MET)

References

[Maina F, et al., MET in nervous system development (2001) (2001)](https://pubmed.ncbi.nlm.nih.gov/11420753/)

[Thompson J, et al., MET and Alzheimer's disease (2014) (2014)](https://pubmed.ncbi.nlm.nih.gov/24904813/)

[Kato T, et al., MET in Parkinson's disease (2018) (2018)](https://pubmed.ncbi.nlm.nih.gov/30135176/)

[Cheng P, et al., MET inhibitors in brain cancer (2019) (2019)](https://pubmed.ncbi.nlm.nih.gov/31199677/)

From the [SciDEX Exchange](/exchange) — scored by multi-agent debate

[The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction](/hypothesis/h-e3e8407c) — <span style="color:#ffd54f;font-weight:600">0.52</span> · Target: TFEB
[The Glial Ketone Metabolic Shunt Hypothesis](/hypothesis/h-4b517512) — <span style="color:#ffd54f;font-weight:600">0.51</span> · Target: HMGCS2
[Brain Insulin Resistance with Glucose Transporter Dysfunction](/hypothesis/h-075f1f02) — <span style="color:#ffd54f;font-weight:600">0.50</span> · Target: GLUT3/GLUT4

Related Analyses:

[Metabolic reprogramming in neurodegenerative disease](/analysis/SDA-2026-04-02-gap-v2-5d0e3052) 🔄

Pathway Diagram

The following diagram shows the key molecular relationships involving MET - MET Proto-Oncogene, Receptor Tyrosine Kinase discovered through SciDEX knowledge graph analysis:

Mermaid diagram (expand to render)

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Related Entities

MET

▸Metadataorigin_type: v1_polymorphic_backfill

slug	genes-met
kg_node_id	MET
entity_type	gene
origin_type	v1_polymorphic_backfill
source_table	wiki_pages
wiki_page_id	wp-a74347e47b13
__merged_from	{'merged_at': '2026-05-13', 'unprefixed_id': 'genes-met'}
_schema_version	1

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

193

Outgoing

207

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Public annotations (0)Annotate on Hypothes.is →

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📗 Cite This Artifact

MET - MET Proto-Oncogene, Receptor Tyrosine Kinase

MET Gene — MET Proto-Oncogene, Receptor Tyrosine Kinase

MET Gene — MET Proto-Oncogene, Receptor Tyrosine Kinase

Pathway Diagram

Introduction

Gene Information

Protein Structure

Normal Neuronal Function

Brain Development

Plasticity and Repair

Astrocyte Function

Expression Pattern

Disease Associations

Alzheimer's Disease

Parkinson's Disease

Brain Cancer

Autism Spectrum Disorders

Signaling Pathways

Therapeutic Targeting

See Also

External Links

References

Pathway Diagram

💬 Discussion

📗 Cite This Artifact

MET - MET Proto-Oncogene, Receptor Tyrosine Kinase

MET Gene — MET Proto-Oncogene, Receptor Tyrosine Kinase

MET Gene — MET Proto-Oncogene, Receptor Tyrosine Kinase

Pathway Diagram

Introduction

Gene Information

Protein Structure

Normal Neuronal Function

Brain Development

Plasticity and Repair

Astrocyte Function

Expression Pattern

Disease Associations

Alzheimer's Disease

Parkinson's Disease

Brain Cancer

Autism Spectrum Disorders

Signaling Pathways

Therapeutic Targeting

See Also

External Links

References

Related Hypotheses

Pathway Diagram

💬 Discussion