concept

GLUT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

155Connections

0Hypotheses

1Analyses

50Outgoing

49Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GLUT3
Related Diseases	Bladder Cancer, Glioblastoma Invasion, Tumor, Cancer, ALS

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GLUT3["GLUT3"]
    GLUT3 -->|"modulates"| Glioblastoma_Invasion["Glioblastoma Invasion"]
    GLUT3 -->|"activates"| Tumor["Tumor"]
    GLUT3 -->|"activates"| Cancer["Cancer"]
    GLUT3 -->|"activates"| ALS["ALS"]
    GLUT3 -->|"activates"| Glioblastoma["Glioblastoma"]
    GLUT3 -->|"target for"| Als["Als"]
    PKM["PKM"] -->|"activates"| GLUT3
    FASN["FASN"] -->|"activates"| GLUT3
    LDHA["LDHA"] -->|"activates"| GLUT3
    HK1["HK1"] -->|"activates"| GLUT3
    HK2["HK2"] -->|"activates"| GLUT3
    HIF["HIF"] -->|"activates"| GLUT3
    AKT["AKT"] -->|"activates"| GLUT3
    AMPK["AMPK"] -->|"activates"| GLUT3

Outgoing (106)

Target	Relation	Type	Str
Bladder Cancer	associated_with	disease	0.85
High-Carbohydrate Diet	upregulates	drug	0.85
Glioblastoma Invasion	modulates	phenotype	0.80
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	regulates	disease	0.65
ALS	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Diabetes	protects_against	disease	0.65
Dementia	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Als	protects_against	disease	0.65
Neuropathy	protects_against	disease	0.65
HIF-1Α	activates	gene	0.60
PI3K	activates	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Mtor	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
FN1	regulates	gene	0.60
GBP2	regulates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
Immune Response	activates	pathway	0.60
Angiogenesis	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
G6PD	activates	gene	0.60
FASN	activates	gene	0.60
GLUT1	activates	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Stem Cell	therapeutic_target	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
FLAVONOIDS	inhibits	gene	0.60
GLUT1	contributes_to	gene	0.60
NF-KB	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
Nf-Kb	inhibits	pathway	0.60
CANCER	inhibits	gene	0.60
AKT	activates	gene	0.60
GBM	regulates	gene	0.60
ASTROCYTE	activates	gene	0.60
PHIP	regulates	gene	0.60

Incoming (49)

Source	Relation	Type	Str
h-075f1f02	targets_gene	hypothesis	0.90
PKM	activates	gene	0.60
FASN	activates	gene	0.60
LDHA	activates	gene	0.60
HK1	activates	gene	0.60
HK2	activates	gene	0.60
HIF	activates	gene	0.60
AKT	activates	gene	0.60
AMPK	activates	gene	0.60
GLUT1	activates	gene	0.60
AND	activates	gene	0.60
LDHB	activates	gene	0.60
CANCER	activates	gene	0.60
GENES	activates	gene	0.60
SRC	activates	gene	0.60
G6PD	activates	gene	0.60
PTEN	activates	gene	0.60
MTOR	activates	gene	0.60
GENES	regulates	gene	0.60
GBM	regulates	gene	0.60
ASTROCYTE	activates	gene	0.60
PHIP	regulates	gene	0.60
ANXA2	regulates	gene	0.60
AND	regulates	gene	0.60
GBP2	regulates	gene	0.60
IL-1	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TNF	inhibits	gene	0.60
FLAVONOIDS	inhibits	gene	0.60
GLUT1	contributes_to	gene	0.60
IL-6	inhibits	gene	0.60
AND	contributes_to	gene	0.60
FN1	regulates	gene	0.60
MAP2	biomarker_for	gene	0.60
GLUT1	biomarker_for	gene	0.60
DEMENTIA	protects_against	gene	0.60
BDNF	biomarker_for	gene	0.60
DNA	protects_against	gene	0.60
CREB	biomarker_for	gene	0.60
GBM	expressed_in	gene	0.60
GLUT1	implicated_in	gene	0.60
AKT	expressed_in	gene	0.60
GLUT1	expressed_in	gene	0.60
GLUT1	translocates_to	gene	0.60
GLUT1	associated_with	gene	0.55
GLUT4	interacts_with	gene	0.50
cbs-psp-daily-action-plan	references	therapeutic	0.40
Tricaprilin Phase 3 ALTER-AD Study (NCT05809908)	references	clinical	0.40
HMGCS2	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolic reprogramming in neurodegenerative disease

neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.398

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GLUT3

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

metabolic-dysfunction-neurodegeneration

Type 3 Diabetes Hypothesis of Alzheimer's Disease

Metabolic Dysfunction in Corticobasal Degeneration

TBX2 — T-Box Transcription Factor 2

Tricaprilin Phase 3 ALTER-AD Study (NCT05809908)

Astrocyte-Neuron Metabolic Coupling Pathway

Metabolic Dysfunction in Alzheimer's Disease

pdp1

mTOR Signaling in Neurodegeneration

Neuropeptide Y Signaling in Neurodegeneration

Metabolic Dysfunction in 4R-Tauopathies

TREH — Trehalase

SLC2A1 Gene

PKM2 Metabolic Dysregulation in Alzheimer's Disease

Akt Signaling Pathway in Neurodegeneration

Hypoxia Response Pathway

Brain Insulin Signaling Pathway