concept

AMPK PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMPK PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

26Outgoing

18Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	AMPK PATHWAY
Key Genes/Proteins	TAU, MTOR, AMPK
Related Diseases	LIPID METABOLISM, NEURODEGENERATION, OXIDATIVE STRESS, ROS, AUTOPHAGY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    AMPK_PATHWAY["AMPK PATHWAY"]
    AMPK_PATHWAY -->|"activates"| TAU["TAU"]
    AMPK_PATHWAY -->|"interacts"| NEURODEGENERATION["NEURODEGENERATION"]
    GMPR1["GMPR1"] -->|"involved_in"| AMPK_PATHWAY
    FIBROBLASTS["FIBROBLASTS"] -->|"regulates"| AMPK_PATHWAY
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| AMPK_PATHWAY
    ROS["ROS"] -->|"activates"| AMPK_PATHWAY
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| AMPK_PATHWAY
    AGING["AGING"] -->|"activates"| AMPK_PATHWAY
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| AMPK_PATHWAY

Outgoing (26)

Target	Relation	Type	Str
LIPID METABOLISM	regulates	phenotype	0.70
TAU	activates	protein	0.65
NEURODEGENERATION	interacts_with	phenotype	0.65
MTOR	inhibits	gene	0.65
ASTROCYTES	associated_with	cell_type	0.50
RESVERATROL	associated_with	drug	0.45
DONEPEZIL	associated_with	drug	0.45
FIBROBLASTS	associated_with	cell_type	0.45
AUTOPHAGY	associated_with	phenotype	0.45
AGING	associated_with	phenotype	0.45
AMPK	associated_with	gene	0.45
TAU	associated_with	protein	0.45
SLC7A11	associated_with	gene	0.45
ROS	associated_with	phenotype	0.45
AMYLOID	associated_with	protein	0.45
ALZHEIMER	associated_with	disease	0.45
APP	associated_with	gene	0.45
SIRT1	associated_with	gene	0.45
STROKE	associated_with	disease	0.45
NEURON	associated_with	cell_type	0.45
METFORMIN	associated_with	drug	0.45
MTOR	associated_with	gene	0.45
NLRP3	associated_with	gene	0.45
STAT3	associated_with	gene	0.45
TLR4	associated_with	gene	0.45
LIRAGLUTIDE	associated_with	drug	0.45

Incoming (19)

Source	Relation	Type	Str
FIBROBLASTS	regulates	cell_type	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
ROS	activates	phenotype	0.65
AUTOPHAGY	activates	phenotype	0.65
AUTOPHAGY	regulates	phenotype	0.65
AGING	activates	phenotype	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
AMPK	protects_against	gene	0.65
AMPK	inhibits	gene	0.65
METFORMIN	activates	drug	0.65
AGING	regulates	phenotype	0.65
OLIGODENDROCYTE	phosphorylates	cell_type	0.65
LIPID METABOLISM	associated_with	phenotype	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.45
NEURODEGENERATION	associated_with	phenotype	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
BLOOD-BRAIN BARRIER DISRUPTION	associated_with	phenotype	0.45
OLIGODENDROCYTE	associated_with	cell_type	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AMPK PATHWAY

Understanding Entity Pages

Wiki Pages (20)

Neuroresilience Mechanisms and Evidence

Autophagy Mechanisms

RPL30 — Ribosomal Protein L30 in Neurodegeneration

Type 3 Diabetes Hypothesis of Alzheimer's Disease

Ferroptotic Neurons

TUBB — Tubulin Beta Class I

PM20D1 Protein

RRAGB — Ras-Related GTP Binding B

Sirtuin Signaling Pathway

epas1-protein

FBXO7 Protein (PARK15)

Neurotensin Signaling in Neurodegeneration

ESRRB Gene

PDK4 (3-Phosphoinositide-Dependent Protein Kinase-4)

SPG35 Gene

pard3

Autophagy Enhancement for Tauopathy

mTOR Signaling in Autophagy and Lysosomal Function