pathway

LIPID METABOLISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIPID METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2339Connections

3Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	LIPID METABOLISM
Linked Hypotheses	5 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"associated"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"associated"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"contributes to"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"contributes to"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"contributes to"| SYNAPTIC_PLASTICITY["SYNAPTIC PLASTICITY"]
    style SYNAPTIC_PLASTICITY fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"associated"| KIDNEY_FIBROSIS["KIDNEY FIBROSIS"]
    style KIDNEY_FIBROSIS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    LIPID_METABOLISM["LIPID METABOLISM"] -->|"expressed in"| TNF["TNF"]
    style TNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CLOCK["CLOCK"] -->|"regulates"| LIPID_METABOLISM["LIPID METABOLISM"]
    style CLOCK fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    BMAL1["BMAL1"] -->|"regulates"| LIPID_METABOLISM["LIPID METABOLISM"]
    style BMAL1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PLIN2["PLIN2"] -->|"regulates"| LIPID_METABOLISM["LIPID METABOLISM"]
    style PLIN2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    RUBCN["RUBCN"] -->|"regulates"| LIPID_METABOLISM["LIPID METABOLISM"]
    style RUBCN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PER["PER"] -->|"regulates"| LIPID_METABOLISM["LIPID METABOLISM"]
    style PER fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style LIPID_METABOLISM fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (321)

Target	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	entity	0.90
PARKINSON'S DISEASE	associated_with	entity	0.90
OXIDATIVE STRESS	contributes_to	entity	0.85
NEUROINFLAMMATION	contributes_to	entity	0.85
SYNAPTIC PLASTICITY	contributes_to	entity	0.80
KIDNEY FIBROSIS	associated_with	entity	0.80
INSULIN RESISTANCE	treats	phenotype	0.70
OXIDATIVE STRESS	causes	phenotype	0.65
PODOCYTES	causes	cell_type	0.65
PODOCYTES	activates	cell_type	0.65
PI3K/AKT/MTOR	inhibits	pathway	0.65
SPHINGOLIPID	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
OXIDATIVE STRESS	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
MACROPHAGES	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
WHITE MATTER	co_discussed	entity	0.50
MTOR	co_discussed	entity	0.50
MACROPHAGES	interacts_with	cell_type	0.50
MACROPHAGES	regulates	cell_type	0.50
PI3K/AKT	regulates	pathway	0.50
WNT	activates	pathway	0.50
Proteins	regulates	protein	0.50
Neurodegenerative Diseases	associated_with	disease	0.50
disease	associated_with	disease	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50
NEURODEGENERATIVE DISORDERS	associated_with	concept	0.50
GENE EXPRESSION	interacts_with	concept	0.50
Proteins	activates	protein	0.50
GLYCOLYSIS	regulates	pathway	0.50
Mitochondrial Function	regulates	pathway	0.50
Astrocytes	expressed_in	cell_type	0.50
disease	expressed_in	disease	0.50
IPSC	expressed_in	concept	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
disease	activates	disease	0.50
DISEASE-ASSOCIATED MICROGLIA	activates	concept	0.50
White Matter	activates	process	0.50
GRAY MATTER	activates	concept	0.50
MTORC1	activates	concept	0.50
HEPATOCYTES	regulates	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
MYELIN	interacts_with	concept	0.50
Cholesterol	interacts_with	pathway	0.50

Incoming (2018)

Source	Relation	Type	Str
CLOCK	regulates	entity	0.90
BMAL1	regulates	entity	0.90
PLIN2	regulates	entity	0.90
RUBCN	regulates	entity	0.85
PER	regulates	entity	0.85
CRY	regulates	entity	0.85
DGAT1	involved_in	entity	0.85
SOAT1	involved_in	entity	0.85
APOA1	involved_in	entity	0.85
CD36	involved_in	entity	0.85
LDLR	regulates	entity	0.85
LRP1	regulates	entity	0.85
APOE	involved_in	entity	0.80
MICROGLIA	destabilizes	cell_type	0.70
DIABETES	interacts_with	disease	0.70
AMPK PATHWAY	regulates	pathway	0.70
SIRT6	regulates	gene	0.70
PHAGOCYTOSIS	inhibits	phenotype	0.65
NEURONS	causes	cell_type	0.65
HEPATOCELLULAR CARCINOMA	targets	disease	0.65
PHAGOCYTOSIS	exacerbates	phenotype	0.65
LRP1	stabilizes	gene	0.60
UBIQUITIN	implicated_in	protein	0.55
CIRCADIAN	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50
GLIOBLASTOMA	co_discussed	entity	0.50
LDLR	co_discussed	entity	0.50
ISCHEMIA	co_discussed	entity	0.50
APOE	co_discussed	entity	0.50
ASTROCYTE	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
FERROPTOSIS	co_discussed	entity	0.50
MICROGLIA	associated_with	cell_type	0.50
MACROPHAGES	associated_with	cell_type	0.50
ALZHEIMER	associated_with	disease	0.50
FERROPTOSIS	associated_with	process	0.50
ALZHEIMER	regulates	disease	0.50
PARKINSON	regulates	disease	0.50
NEUROINFLAMMATION	regulates	process	0.50
OXIDATIVE STRESS	regulates	process	0.50
APOE	regulates	gene	0.50
TAU	regulates	protein	0.50
AKT	regulates	gene	0.50
PI3K	regulates	gene	0.50
INFLAMMATION	regulates	process	0.50
INFLAMMATION	associated_with	process	0.50
IL-6	associated_with	gene	0.50
TNF	associated_with	gene	0.50
CANCER	inhibits	disease	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte APOE4-Specific Lipid Metabolism Correction	0.479	neurodegeneration	Cell type vulnerability in Alzheimers Di
Sphingolipid Metabolism Reprogramming	0.443	neurodegeneration	4R-tau strain-specific spreading pattern
APOE4-Lipid Metabolism Correction	0.425	neurodegeneration	Neuroinflammation and microglial priming

Mentioning Analyses (2)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses