Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATP1A3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | ATP1A3 |
| Full Name | ATPase Na+/K+ Transporting Subunit Alpha 3 |
| Chromosome | 19q13.2 |
| Function | The Na+/K+-ATPase is an essential electrogenic pump that maintains the resting membrane potential and regulates cellular volume. |
| Molecular Weight | 111 kDa |
| UniProt ID | P13637 |
| NCBI Gene ID | 478 |
| Ensembl ID | ENSG00000105409 |
| OMIM | 168500 |
| GeneCards | ATP1A3 |
| Human Protein Atlas | ATP1A3 |
| Ion Transport | Active transport of 3 Na+ out and 2 K+ into neurons per ATP hydrolyzed |
| Membrane Potential | Establishes and maintains the neuronal resting membrane potential (-70 to -90 mV) |
| Secondary Transport | Powers secondary active transporters including glutamate transporters |
| Calcium Regulation | Indirectly affects calcium homeostasis through Na+/Ca2+ exchangers |
| Associated Diseases | Als, Alzheimer, Parkinson |
| Interactions | IL1B |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["ATP1A3"]
N1["Alzheimer"]
N0 -->|"associated with"| N1
N2["Als"]
N0 -->|"associated with"| N2
N3["Parkinson"]
N0 -->|"associated with"| N3
N4["SNCA"]
N0 -->|"associated with"| N4
N5["PARKINSON"]
N0 -->|"associated with"| N5
N6["LRRK2"]
N0 -->|"associated with"| N6
N7["GCH1"]
N7 -->|"associated with"| N0
N8["VPS35"]
N8 -->|"associated with"| N0
N9["GBA1"]
N9 -->|"associated with"| N0
N10["TARDBP"]
N10 -->|"associated with"| N0
N11["PARK7"]
N11 -->|"associated with"| N0
N12["DNAJC13"]
N12 -->|"associated with"| N0
N13["ALZHEIMER"]
N13 -->|"associated with"| N0
N14["FBXO7"]
N14 -->|"associated with"| N0
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
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classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 disease
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene
class N9 gene
class N10 gene
class N11 gene
class N12 gene
class N13 gene
class N14 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| SNCA | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| IL1B | activates | gene | 0.60 |
| GLUD1 | associated_with | gene | 0.60 |
| DNAJC13 | associated_with | gene | 0.60 |
| DNAJC6 | associated_with | gene | 0.60 |
| FBXO7 | associated_with | gene | 0.60 |
| GBA1 | associated_with | gene | 0.60 |
| GCH1 | associated_with | gene | 0.60 |
| PARK7 | associated_with | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| PLA2G6 | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| TARDBP | associated_with | gene | 0.60 |
| VPS13C | associated_with | gene | 0.60 |
| VPS35 | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| mitochondrial function | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GCH1 | associated_with | gene | 0.60 |
| VPS35 | associated_with | gene | 0.60 |
| GBA1 | associated_with | gene | 0.60 |
| TARDBP | associated_with | gene | 0.60 |
| PARK7 | associated_with | gene | 0.60 |
| DNAJC13 | associated_with | gene | 0.60 |
| FBXO7 | associated_with | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| VPS13C | associated_with | gene | 0.60 |
| DNAJC6 | associated_with | gene | 0.60 |
| ATP13A2 | associated_with | gene | 0.60 |
| PLA2G6 | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| ARRB2 | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||