gene

ATP1A3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP1A3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections
0Hypotheses
0Analyses
21Outgoing
15Incoming
0Experiments

Summary

ATP1A3 - sodium-potassium ATPase linked to dystonia-parkinsonism

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🧬 Gene Info
Gene SymbolATP1A3
Full NameATPase Na+/K+ Transporting Subunit Alpha 3
Chromosome19q13.2
FunctionThe Na+/K+-ATPase is an essential electrogenic pump that maintains the resting membrane potential and regulates cellular volume.
Molecular Weight111 kDa
UniProt IDP13637
NCBI Gene ID478
Ensembl IDENSG00000105409
OMIM168500
GeneCardsATP1A3
Human Protein AtlasATP1A3
Ion TransportActive transport of 3 Na+ out and 2 K+ into neurons per ATP hydrolyzed
Membrane PotentialEstablishes and maintains the neuronal resting membrane potential (-70 to -90 mV)
Secondary TransportPowers secondary active transporters including glutamate transporters
Calcium RegulationIndirectly affects calcium homeostasis through Na+/Ca2+ exchangers
Associated DiseasesAls, Alzheimer, Parkinson
InteractionsIL1B
KG Connections36 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: ATP1A3 — AlphaFold P13637 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

ATP1A3 Gene - Sodium-Potassium ATPase Alpha 3

gene · 973 words

calcium-dysregulation-comparison

mechanism · 6468 words

Regulated Necrosis Hypothesis in Parkinson's Disease

hypothesis · 3098 words

Maria Stamelou — PSP and Tauopathy Researcher

researcher · 3075 words

ATP13A2 (PARK9) Pathway in Parkinson's Disease

mechanism · 2534 words

ATP1A2 Gene

gene · 1883 words

Pathway Diagram

flowchart TD
    N0["ATP1A3"]
    N1["Alzheimer"]
    N0 -->|"associated with"| N1
    N2["Als"]
    N0 -->|"associated with"| N2
    N3["Parkinson"]
    N0 -->|"associated with"| N3
    N4["SNCA"]
    N0 -->|"associated with"| N4
    N5["PARKINSON"]
    N0 -->|"associated with"| N5
    N6["LRRK2"]
    N0 -->|"associated with"| N6
    N7["GCH1"]
    N7 -->|"associated with"| N0
    N8["VPS35"]
    N8 -->|"associated with"| N0
    N9["GBA1"]
    N9 -->|"associated with"| N0
    N10["TARDBP"]
    N10 -->|"associated with"| N0
    N11["PARK7"]
    N11 -->|"associated with"| N0
    N12["DNAJC13"]
    N12 -->|"associated with"| N0
    N13["ALZHEIMER"]
    N13 -->|"associated with"| N0
    N14["FBXO7"]
    N14 -->|"associated with"| N0

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 gene
    class N11 gene
    class N12 gene
    class N13 gene
    class N14 gene

Outgoing (21)

TargetRelationTypeStr
Alzheimerassociated_withdisease0.65
Alsassociated_withdisease0.65
Parkinsonassociated_withdisease0.65
SNCAassociated_withgene0.60
LRRK2associated_withgene0.60

Incoming (15)

SourceRelationTypeStr
GCH1associated_withgene0.60
VPS35associated_withgene0.60
GBA1associated_withgene0.60
TARDBPassociated_withgene0.60
PARK7associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found