concept

SORLA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SORLA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

105Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SORLA Gene
Summary	Page for SORLA Gene
Related Diseases	Diabetes, Bipolar, Als, Coronary Artery Disease, Alzheimer

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SORLA["SORLA"]
    SORLA -->|"implicated in"| Diabetes["Diabetes"]
    SORLA -->|"implicated in"| Bipolar["Bipolar"]
    SORLA -->|"implicated in"| Als["Als"]
    SORLA -->|"implicated in"| Coronary_Artery_Disease["Coronary Artery Disease"]
    SORLA -->|"implicated in"| Alzheimer["Alzheimer"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"inhibits"| SORLA
    AND["AND"] -->|"inhibits"| SORLA
    LYSOSOME["LYSOSOME"] -->|"activates"| SORLA
    MICROGLIA["MICROGLIA"] -->|"contributes to"| SORLA
    ALZHEIMER["ALZHEIMER"] -->|"inhibits"| SORLA
    AMYLOID["AMYLOID"] -->|"activates"| SORLA
    SORL1["SORL1"] -->|"inhibits"| SORLA

Outgoing (73)

Target	Relation	Type	Str
Diabetes	implicated_in	disease	0.65
Bipolar	implicated_in	disease	0.65
Als	implicated_in	disease	0.65
Coronary Artery Disease	implicated_in	disease	0.65
Alzheimer	implicated_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	contributes_to	disease	0.65
Alzheimer	causes	disease	0.65
Als	activates	disease	0.65
Alzheimer	contributes_to	disease	0.65
Obesity	contributes_to	disease	0.65
Atherosclerosis	contributes_to	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
ALS	activates	disease	0.65
ALS	associated_with	disease	0.65
Als	expressed_in	disease	0.65
SORCS1	associated_with	gene	0.60
APP	implicated_in	gene	0.60
APP	interacts_with	protein	0.60
VPS10	associated_with	protein_family	0.60
obesity	associated_with	disease	0.60
SORCS3	associated_with	gene	0.60
APP	inhibits	gene	0.60
SORCS2	associated_with	gene	0.60
NGF	associated_with	gene	0.60
TAU	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
PKC	activates	gene	0.60
Rb	expressed_in	protein	0.60
GBM	expressed_in	gene	0.60
Rb	inhibits	protein	0.60
neurodegeneration	activates	disease	0.60
ALZHEIMER	implicated_in	gene	0.60
AMYLOID	implicated_in	gene	0.60
ALZHEIMER'S DISEASE	implicated_in	gene	0.60
Exocytosis	contributes_to	pathway	0.60
Immune Response	contributes_to	pathway	0.60
Lysosomal Degradation	inhibits	pathway	0.60
Alzheimer's disease	protects_against	disease	0.60
atherosclerosis	associated_with	disease	0.60
Neuron	interacts_with	cell_type	0.60
Neurogenesis	regulates	pathway	0.60
Neuron	regulates	cell_type	0.60
ALZHEIMER	causes	gene	0.60
AND	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
AMYLOID	inhibits	gene	0.60
Amyloid	inhibits	pathway	0.60

Incoming (32)

Source	Relation	Type	Str
SORL1	inhibits	gene	0.60
SORL1	encodes	gene	0.60
PKCι	regulates	protein	0.60
ARRB2	regulates	protein	0.60
SORL1	associated_with	gene	0.60
APP	inhibits	gene	0.60
PKC	activates	gene	0.60
SORCS1	associated_with	gene	0.60
SORCS2	associated_with	gene	0.60
NGF	associated_with	gene	0.60
TAU	associated_with	gene	0.60
SORCS3	associated_with	gene	0.60
TNF	transports	gene	0.60
SORL1	causes	gene	0.60
LDLR	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
AND	inhibits	gene	0.60
LYSOSOME	activates	gene	0.60
MICROGLIA	contributes_to	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID	activates	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER	causes	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	expressed_in	gene	0.60
PRESENILIN	expressed_in	gene	0.60
AND	causes	gene	0.60
ALZHEIMER'S DISEASE	contributes_to	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
MICROGLIA	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SORLA

Understanding Entity Pages

Wiki Pages (21)

SORLA Gene

omega-3-fatty-acids-neurodegeneration

Retromer Dysfunction in Corticobasal Syndrome

Amyloid Precursor Protein (APP)

SNX3 Protein — Sorting Nexin 3 in Neurodegeneration

SORL1 Protein

Retrograde Axonal Transport Dysfunction in Neurodegeneration

Neuritic Plaques

Transcriptional Dysregulation in Neurodegeneration

SORCS3 Gene

protein-trafficking-pathways

SORL1→APP Trafficking→Retromer Dysfunction→Aβ Accumulation→AD Causal Chain

DNAJC13→Endosomal Dysfunction→PD Causal Chain

Retromer Complex

Sortilin Protein

VPS29 Gene

SORCS1 Gene

SNX6 Protein (Sorting Nexin 6)

SORT1 Gene