Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BAP1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, activates. Associated with Als, Cancer, Carcinoma. Connected to 32 entities in the SciDEX knowledge graph.
| Gene Symbol | BAP1 |
| Full Name | BRCA1-Associated Protein 1 |
| Chromosome | 3p21.1 |
| Protein Type | Hydrolase |
| Function | encodes a nuclear deubiquitinase (DUB) of the ubiquitin C-terminal hydrolase (UCH) family that plays essential roles in chromatin regulation, DNA damage response, and cell fate determination. |
| Primary Expression | tyrosine hydroxylase-positive dopaminergic neurons |
| Pathways | Epigenetic, Ferroptosis |
| UniProt ID | [Q92560](https://www.uniprot.org/uniprot/Q92560) |
| Ensembl ID | ENSG00000163930 |
| GeneCards | BAP1 |
| Human Protein Atlas | BAP1 |
| DNA damage response | BAP1 is rapidly recruited to DNA double-strand breaks where it deubiquitinates H2AK119 to facilitate homologous recombination repair and checkpoint activation |
| Metabolic regulation | BAP1 regulates calcium signaling through the IP3 receptor, linking chromatin remodeling to cellular metabolic state |
| Cell death regulation | BAP1 promotes ferroptosis by repressing SLC7A11 (the cystine/glutamate antiporter), thereby modulating oxidative stress sensitivity |
| Associated Diseases | ALS, Cancer, Carcinoma, Melanoma, Ovarian Cancer |
| Interactions | BRCA1, SLC7A11, FERROPTOSIS, UBIQUITIN |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BAP1["<b>BAP1</b>"]
Ms{"Ms"}
BAP1 -->|"inhibits"| Ms
Cancer{"Cancer"}
BAP1 -->|"associated with"| Cancer
Tumor{"Tumor"}
BAP1 -->|"inhibits"| Tumor
FERROPTOSIS["FERROPTOSIS"]
BAP1 -->|"inhibits"| FERROPTOSIS
CANCER["CANCER"]
BAP1 -->|"associated with"| CANCER
BRCA1["BRCA1"]
BAP1 -->|"inhibits"| BRCA1
SLC7A11["SLC7A11"]
BAP1 -->|"inhibits"| SLC7A11
Ferroptosis(["Ferroptosis"])
BAP1 -->|"inhibits"| Ferroptosis
Epigenetic(["Epigenetic"])
BAP1 -->|"inhibits"| Epigenetic
BAP1 -->|"activates"| FERROPTOSIS
BAP1 -->|"activates"| SLC7A11
ATF4["ATF4"]
BAP1 -->|"regulates"| ATF4
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"activates"| BAP1
style BAP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | associated_with | disease | 0.85 |
| Als | associated_with | disease | 0.75 |
| BRCA1 | interacts_with | gene | 0.70 |
| Ms | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Ovarian Cancer | associated_with | disease | 0.65 |
| Melanoma | associated_with | disease | 0.65 |
| Pancreatic Cancer | associated_with | disease | 0.65 |
| Renal Cell Carcinoma | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| BRCA1 | inhibits | gene | 0.60 |
| SLC7A11 | inhibits | gene | 0.60 |
| SLC7A11 | activates | gene | 0.60 |
| ATF4 | regulates | gene | 0.60 |
| NRF2 | regulates | gene | 0.60 |
| POT1 | associated_with | gene | 0.60 |
| BRCA1 | expressed_in | gene | 0.60 |
| BRCA1 | regulates | gene | 0.60 |
| FERROPTOSIS | inhibits | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| Ferroptosis | inhibits | pathway | 0.60 |
| Epigenetic | inhibits | pathway | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| DNA | associated_with | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| DNA | regulates | gene | 0.60 |
| BRCA1 | co_expressed_with | protein | 0.50 |
| PARP1 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||