disease

Renal Cell Carcinoma

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Renal Cell Carcinoma: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

172Connections

0Hypotheses

0Analyses

41Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	INFLAMMATION, IL6, TP53, PTEN, CDKN2A, BAP1, DNA, MMP9
KG Connections	161 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Renal_Cell_Carcinoma["Renal Cell Carcinoma"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
    Renal_Cell_Carcinoma["Renal Cell Carcinoma"] -->|"associated"| Metastasis["Metastasis"]
    Renal_Cell_Carcinoma["Renal Cell Carcinoma"] -->|"therapeutic target"| Apoptosis["Apoptosis"]
    Renal_Cell_Carcinoma["Renal Cell Carcinoma"] -->|"regulates"| Carcinoma["Carcinoma"]
    Renal_Cell_Carcinoma["Renal Cell Carcinoma"] -->|"activates"| Carcinoma_1["Carcinoma"]
    Renal_Cell_Carcinoma["Renal Cell Carcinoma"] -->|"therapeutic target"| Carcinoma_2["Carcinoma"]
    Tumor["Tumor"] -.->|"inhibits"| Renal_Cell_Carcinoma["Renal Cell Carcinoma"]
    VHL["VHL"] -->|"activates"| Renal_Cell_Carcinoma["Renal Cell Carcinoma"]
    HIF["HIF"] -->|"activates"| Renal_Cell_Carcinoma["Renal Cell Carcinoma"]
    CANCER["CANCER"] -->|"activates"| Renal_Cell_Carcinoma["Renal Cell Carcinoma"]
    style Renal_Cell_Carcinoma fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (48)

Target	Relation	Type	Str
Oxidative Stress	activates	pathway	0.70
Metastasis	associated_with	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Carcinoma	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Metastasis	therapeutic_target	pathway	0.60
Mtor	regulates	pathway	0.60
Drug Resistance	therapeutic_target	pathway	0.60
Glycolysis	regulates	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Cell Cycle	inhibits	pathway	0.60
Angiogenesis	inhibits	pathway	0.60
Mtor	activates	pathway	0.60
Autophagy	inhibits	pathway	0.60
Ferroptosis	activates	pathway	0.60
Homologous Recombination	activates	pathway	0.60
Receptor Tyrosine Kinase	inhibits	pathway	0.60
Stem Cell	activates	pathway	0.60
Mapk	activates	pathway	0.60
Tumor Microenvironment	activates	pathway	0.60
Pyroptosis	activates	pathway	0.60
Immunotherapy	activates	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Mtor	treats	pathway	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Carcinoma	expressed_in	disease	0.55
Inflammation	associated_with	disease	0.55
Arrhythmia	activates	disease	0.55
Als	associated_with	disease	0.55
Als	contributes_to	disease	0.55
Carcinoma	causes	disease	0.55
Als	activates	disease	0.55
Carcinoma	associated_with	disease	0.55
Lymphoma	treats	disease	0.55
Carcinoma	treats	disease	0.55
Als	treats	disease	0.55
NEUTROPHILS	activates	concept	0.50

Incoming (124)

Source	Relation	Type	Str
Ferroptosis	associated_with	process	0.85
Tumor	inhibits	disease	0.75
VHL	activates	gene	0.75
HIF	activates	gene	0.75
CANCER	activates	gene	0.75
Tumor	activates	disease	0.75
APOPTOSIS	therapeutic_target	gene	0.75
PIEZO1	therapeutic_target	gene	0.75
Ferroptosis	involved_in	process	0.75
ferroptosis	implicated_in	process	0.70
AKT	regulates	gene	0.65
MTOR	regulates	gene	0.65
APOPTOSIS	inhibits	gene	0.65
PI3K	inhibits	gene	0.65
CANCER	inhibits	gene	0.65
AKT	inhibits	gene	0.65
MTOR	inhibits	gene	0.65
Carcinoma	inhibits	disease	0.65
MITOCHONDRIAL DYSFUNCTION	expressed_in	gene	0.65
HNF4A	expressed_in	gene	0.65
CANCER	expressed_in	gene	0.65
GENES	expressed_in	gene	0.65
Tumor	expressed_in	disease	0.65
PI3K	activates	gene	0.65
RAS	activates	gene	0.65
GENES	activates	gene	0.65
AKT	activates	gene	0.65
MYC	activates	gene	0.65
MTOR	activates	gene	0.65
Cancer	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
ATG14L	inhibits	gene	0.65
BECLIN1	inhibits	gene	0.65
AUTOPHAGY	inhibits	gene	0.65
CDKN2A	activates	gene	0.65
OXIDATIVE STRESS	activates	gene	0.65
BRCA1	activates	gene	0.65
BRCA2	activates	gene	0.65
FERROPTOSIS	activates	gene	0.65
MITOCHONDRIA	activates	gene	0.65
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.65
DNA	activates	gene	0.65
INFLAMMATION	associated_with	gene	0.65
IL6	associated_with	gene	0.65
TP53	associated_with	gene	0.65
PTEN	associated_with	gene	0.65
CDKN2A	associated_with	gene	0.65
CANCER	therapeutic_target	gene	0.65
BAP1	associated_with	gene	0.65
DNA	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Renal Cell Carcinoma

Understanding Entity Pages

Wiki Pages (20)

Litronesib (LY317615/Enzastaurin)

PDCD10 Gene (Programmed Cell Death 10)

Interleukin-2 Phase 2 (NCT06096090) — Immunomodulation for AD

NPRL2 Gene

LRRK2 Signaling Pathway in Parkinson's Disease

LGI2 — Leucine-Rich Glioma Inactivated 2

DEPTOR

Axl Protein

HNF4A - Hepatocyte Nuclear Factor 4 Alpha

mTOR Signaling Pathway in Neurodegeneration

Hereditary Paraganglioma

Pheochromocytoma

PAX2 Gene

SETD2 Gene

CBL Gene

BAP1 (BRCA1-Associated Protein 1)

FBP1 Gene

KCNK10 Gene