POT1

Understanding Entity Pages

This page aggregates everything SciDEX knows about POT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

POT1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with Als, Cancer, Melanoma. Connected to 56 entities in the SciDEX knowledge graph.

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graph TD
    POT1["<b>POT1</b>"]
    Als{"Als"}
    POT1 -->|"interacts with"| Als
    Senescence{"Senescence"}
    POT1 -->|"interacts with"| Senescence
    Ms{"Ms"}
    POT1 -->|"interacts with"| Ms
    TPP1["TPP1"]
    POT1 -->|"interacts with"| TPP1
    Akt(["Akt"])
    POT1 -->|"interacts with"| Akt
    MRE11["MRE11"]
    POT1 -->|"interacts with"| MRE11
    MUTYH["MUTYH"]
    POT1 -->|"interacts with"| MUTYH
    SAMHD1["SAMHD1"]
    POT1 -->|"interacts with"| SAMHD1
    NBS1["NBS1"]
    POT1 -->|"interacts with"| NBS1
    LMNA["LMNA"]
    POT1 -->|"interacts with"| LMNA
    WRN["WRN"]
    POT1 -->|"interacts with"| WRN
    MDM2["MDM2"]
    POT1 -->|"interacts with"| MDM2
    TREX1["TREX1"]
    TREX1 -->|"interacts with"| POT1
    VCP["VCP"]
    VCP -->|"interacts with"| POT1
    NEIL1["NEIL1"]
    NEIL1 -->|"interacts with"| POT1
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"interacts with"| POT1
    POLD1["POLD1"]
    POLD1 -->|"interacts with"| POT1
    P53["P53"]
    P53 -->|"interacts with"| POT1
    style POT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0