Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CNBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive review of CNBP gene, a zinc-finger protein implicated in Myotonic Dystrophy Type 2 and neurodegenerative disease pathogenesis
| Gene Symbol | CNBP |
| Full Name | Cellular Nucleic Acid Binding Protein |
| Chromosome | 3q21.3 |
| Protein Family | CCHC-type zinc finger |
| Function | is a human gene located on chromosome 3q21. |
| Primary Expression | Skeletal muscle, Heart, Brain, Spinal cord |
| Amino Acids | 182 aa |
| UniProt ID | Q9GZL0 |
| NCBI Gene ID | 28985 |
| Ensembl ID | ENSG00000182021 |
| OMIM | 116955 |
| GeneCards | CNBP |
| Human Protein Atlas | CNBP |
| Alias | ZNF9, ZNF7 |
| Protein Length | 182 amino acids |
| Associated Diseases | ALS, Amyotrophic Lateral Sclerosis, Myotonic Dystrophy Type 2, Neurodegeneration, Parkinson's disease, Tauopathy |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CNBP["<b>CNBP</b>"]
Als{"Als"}
CNBP -->|"therapeutic target"| Als
Ms{"Ms"}
CNBP -->|"therapeutic target"| Ms
MTDNA["MTDNA"]
CNBP -->|"therapeutic target"| MTDNA
Autophagy(["Autophagy"])
CNBP -->|"therapeutic target"| Autophagy
Mitophagy(["Mitophagy"])
CNBP -->|"therapeutic target"| Mitophagy
neurodegeneration["neurodegeneration"]
CNBP -->|"implicated in"| neurodegeneration
BNIP3["BNIP3"]
BNIP3 -->|"therapeutic target"| CNBP
MITOPHAGY["MITOPHAGY"]
MITOPHAGY -->|"therapeutic target"| CNBP
P62["P62"]
P62 -->|"therapeutic target"| CNBP
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
MITOCHONDRIAL_DNA -->|"therapeutic target"| CNBP
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
MITOCHONDRIAL_DYSFUNCTION -->|"therapeutic target"| CNBP
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"therapeutic target"| CNBP
style CNBP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Myotonic Dystrophy Type 2 | causes | disease | 0.95 |
| Als | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Tauopathy | associated_with | disease | 0.65 |
| GAIN | associated_with | gene | 0.60 |
| RAN | associated_with | gene | 0.60 |
| DMPK | associated_with | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| NPC1 | associated_with | gene | 0.60 |
| NPC2 | associated_with | gene | 0.60 |
| MTDNA | therapeutic_target | gene | 0.60 |
| Autophagy | therapeutic_target | pathway | 0.60 |
| Mitophagy | therapeutic_target | pathway | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 0.60 |
| MITOPHAGY | therapeutic_target | gene | 0.60 |
| AUTOPHAGY | therapeutic_target | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 0.60 |
| ZNF9/CNBP | associated_with | gene | 0.60 |
| TAUOPATHY | associated_with | gene | 0.60 |
| frontotemporal dementia | associated_with | disease | 0.60 |
| Parkinson's disease | associated_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BNIP3 | therapeutic_target | gene | 0.60 |
| P62 | therapeutic_target | gene | 0.60 |
| MITOPHAGY | therapeutic_target | gene | 0.60 |
| MITOCHONDRIAL DNA | therapeutic_target | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 0.60 |
| AUTOPHAGY | therapeutic_target | gene | 0.60 |
| DNA | therapeutic_target | gene | 0.60 |
| MITOCHONDRIA | therapeutic_target | gene | 0.60 |
| MTDNA | therapeutic_target | gene | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||